PMID- 16529908
OWN - NLM
STAT- MEDLINE
DCOM- 20060628
LR  - 20161128
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 28
IP  - 2
DP  - 2006 Mar-Apr
TI  - Prenatal cocaine alters dopamine and sigma receptor binding in nucleus accumbens 
      and striatum in dams and adolescent offspring.
PG  - 173-80
AB  - Maternal cocaine abuse is a societal problem with serious impact on both mother 
      and child. Few studies exist that study the mother/offspring dyad of neurological 
      effects of maternal cocaine abuse. The present study was designed to study 
      alterations in D2, D3 and sigma receptor density in nucleus accumbens and 
      striatum of dams and male and female offspring following gestational cocaine. 
      Long-Evans female rats were implanted with an intravenous (i.v.) access port 
      prior to breeding and were administered saline or 3.0 mg/kg of cocaine from 
      gestational day (GD) GD8-20 (1 injection/day-GD8-14, 2 injections/day-GD15-20). 
      Offspring were raised by maternal dams and allowed to mature until postnatal days 
      31-35, at which time dams and offspring were sacrificed for assay of radioligand 
      binding. In dams, decreased D2 (24.6%) and D3 (36.9%) binding was observed in 
      striatum. Female offspring displayed no differences in receptor binding in either 
      region. Male offspring displayed decreased D2 receptor binding (27.1%) in nucleus 
      accumbens and increased D3 (75.2% and 33.5%) and sigma receptor binding (73.4% 
      and 53.1%) in accumbens and striatum, respectively. Collectively, these data 
      clearly demonstrate that male offspring exhibit significant alterations in D2, D3 
      and sigma receptor binding. These results suggest that dams and offspring display 
      long-lasting alterations (5 weeks) in dopamine receptor binding. These 
      alterations in dopamine and sigma receptor binding in offspring following 
      prenatal cocaine and rearing by maternal dams are sex specific and could have 
      profound effects on the development of behavior.
FAU - Silvers, J M
AU  - Silvers JM
AD  - University of South Carolina, Department of Psychology, Physiology and 
      Pharmacology, Program in Behavioral Neuroscience, Columbia, SC 29208, USA. 
      silversj@gwm.sc.edu
FAU - Wallace, D R
AU  - Wallace DR
FAU - Harrod, S B
AU  - Harrod SB
FAU - Mactutus, C F
AU  - Mactutus CF
FAU - Booze, R M
AU  - Booze RM
LA  - eng
GR  - DA013965/DA/NIDA NIH HHS/United States
GR  - R01 DA013137-04S1/DA/NIDA NIH HHS/United States
GR  - R01 DA013137-05/DA/NIDA NIH HHS/United States
GR  - DA014401/DA/NIDA NIH HHS/United States
GR  - DA013137/DA/NIDA NIH HHS/United States
GR  - DA009160/DA/NIDA NIH HHS/United States
GR  - R01 DA013137/DA/NIDA NIH HHS/United States
GR  - HD043680/HD/NICHD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060309
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Benzamides)
RN  - 0 (Guanidines)
RN  - 0 (Isotopes)
RN  - 0 (Pyrrolidines)
RN  - 0 (Receptors, Dopamine)
RN  - 0 (Receptors, sigma)
RN  - 0 (Tetrahydronaphthalenes)
RN  - 107188-87-4 (epidepride)
RN  - I5Y540LHVR (Cocaine)
RN  - LL2P01I17O (1,3-ditolylguanidine)
RN  - RR7D75YDF4 (7-hydroxy-2-N,N-dipropylaminotetralin)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Autoradiography/methods
MH  - Behavior, Animal/drug effects
MH  - Benzamides/pharmacokinetics
MH  - Cocaine/toxicity
MH  - Corpus Striatum/*drug effects/metabolism
MH  - Female
MH  - Gestational Age
MH  - Guanidines/*pharmacokinetics
MH  - Isotopes/pharmacokinetics
MH  - Male
MH  - Nucleus Accumbens/*drug effects/metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/*metabolism
MH  - Protein Binding/drug effects
MH  - Pyrrolidines/pharmacokinetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine/classification/drug effects/*metabolism
MH  - Receptors, sigma/drug effects/*metabolism
MH  - Sex Factors
MH  - Tetrahydronaphthalenes/pharmacokinetics
EDAT- 2006/03/15 09:00
MHDA- 2006/06/29 09:00
CRDT- 2006/03/15 09:00
PHST- 2005/07/28 00:00 [received]
PHST- 2006/01/05 00:00 [revised]
PHST- 2006/01/09 00:00 [accepted]
PHST- 2006/03/15 09:00 [pubmed]
PHST- 2006/06/29 09:00 [medline]
PHST- 2006/03/15 09:00 [entrez]
AID - S0892-0362(06)00022-5 [pii]
AID - 10.1016/j.ntt.2006.01.009 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2006 Mar-Apr;28(2):173-80. doi: 10.1016/j.ntt.2006.01.009. 
      Epub 2006 Mar 9.