PMID- 16530518
OWN - NLM
STAT- MEDLINE
DCOM- 20060406
LR  - 20181201
IS  - 0016-5085 (Print)
IS  - 0016-5085 (Linking)
VI  - 130
IP  - 3
DP  - 2006 Mar
TI  - Brain-derived neurotrophic factor augments peristalsis by augmenting 5-HT and 
      calcitonin gene-related peptide release.
PG  - 771-80
AB  - BACKGROUND & AIMS: Brain-derived neurotrophic factor (BDNF) acts rapidly to 
      modulate synaptic neurotransmission in the brain. Although present in neurons, 
      glial cells, and mucosal cells of the colon, and in higher concentrations than in 
      brain, the action of BDNF in gut have not been characterized. The aim of this 
      study was to identify the role of BDNF in mediating the peristaltic reflex. 
      METHODS: BDNF and a specific antiserum were examined for their effects on the 
      peristaltic reflex and release of the sensory mediators serotonin and calcitonin 
      gene-related peptide in rat colon. The peristaltic reflex and release of 
      serotonin and calcitonin gene-related peptide were also examined in genetically 
      modified mice (BDNF(+/-)) with reduced levels of BDNF. RESULTS: Endogenous 
      brain-derived neurotrophic factor was released into the sensory compartment in a 
      stimulus-dependent manner during the peristaltic reflex induced by mucosal 
      stimulation but not muscle stretch. BDNF stimulated and immunoneutralization of 
      endogenous BDNF reduced ascending contraction and descending relaxation of 
      circular muscle and release of serotonin and calcitonin gene-related peptide 
      during the peristaltic reflex induced by mucosal stimulation but not muscle 
      stretch. The peristaltic reflex and release of serotonin and calcitonin 
      gene-related peptide during the peristaltic reflex induced by mucosal stimulation 
      but not muscle stretch were significantly reduced in BDNF(+/-) mice. CONCLUSIONS: 
      Endogenous BDNF enhances the peristaltic reflex by augmenting the release of 
      serotonin and calcitonin gene-related peptide that mediate the sensory limb of 
      the reflex induced by mucosal stimulation.
FAU - Grider, John R
AU  - Grider JR
AD  - Departments of Physiology and Internal Medicine, Medical College of Virginia 
      Campus, Virginia Commonwealth University, Richmond, Virginia, USA. 
      jgirder@hsc.vcu.edu
FAU - Piland, Barbara E
AU  - Piland BE
FAU - Gulick, Melisa A
AU  - Gulick MA
FAU - Qiao, Li Ya
AU  - Qiao LY
LA  - eng
GR  - R01 DK034153/DK/NIDDK NIH HHS/United States
GR  - DK34153/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Gastroenterology
JT  - Gastroenterology
JID - 0374630
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 333DO1RDJY (Serotonin)
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Calcitonin Gene-Related Peptide/*metabolism
MH  - Mice
MH  - Peristalsis/*physiology
MH  - Rats
MH  - Reflex
MH  - Serotonin/*metabolism
EDAT- 2006/03/15 09:00
MHDA- 2006/04/07 09:00
CRDT- 2006/03/15 09:00
PHST- 2005/09/16 00:00 [received]
PHST- 2005/12/07 00:00 [accepted]
PHST- 2006/03/15 09:00 [pubmed]
PHST- 2006/04/07 09:00 [medline]
PHST- 2006/03/15 09:00 [entrez]
AID - S0016-5085(05)02536-9 [pii]
AID - 10.1053/j.gastro.2005.12.026 [doi]
PST - ppublish
SO  - Gastroenterology. 2006 Mar;130(3):771-80. doi: 10.1053/j.gastro.2005.12.026.