PMID- 16530956
OWN - NLM
STAT- MEDLINE
DCOM- 20060804
LR  - 20220309
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 400
IP  - 1-2
DP  - 2006 May 29
TI  - c-fos modulates brain-derived neurotrophic factor mRNA expression in mouse 
      hippocampal CA3 and dentate gyrus neurons.
PG  - 177-80
AB  - Excess neuronal excitation by glutamate induces neuron cell death, which may 
      contribute to the pathogenesis of acute brain injuries and neurodegenerative 
      diseases. Our previous studies using a mouse with hippocampal c-fos gene deletion 
      showed that c-fos regulates neuronal excitability and excitotoxicity. Moreover, a 
      delayed induction of brain-derived neurotrophic factor (BDNF) protein expression 
      in response to kainic acid (KA) treatment was found in c-fos mutant mice compared 
      to wildtype controls, suggesting that c-fos is important in the temporal control 
      of BDNF induction. To further investigate mechanisms of in vivo regulation of 
      c-fos on BDNF expression, we studied the expression of BDNF mRNA and its 
      colocalization with c-Fos protein in the hippocampal formation in the presence 
      and absence of KA. By in situ hybridization, we observed that the c-fos mutant 
      and wildtype mice exhibited similar basal expression of BDNF in the absence of 
      KA. In contrast, the KA-induced BDNF mRNA levels were significantly different in 
      wildtype and c-fos mutant mice in CA3 and dentate gyrus regions. Our findings 
      indicate that c-fos regulates expression of BDNF in distinct neuron populations 
      of the hippocampal formation in vivo.
FAU - Dong, Mei
AU  - Dong M
AD  - Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati 
      College of Medicine, Cincinnati, OH 45267, USA.
FAU - Wu, Yongfei
AU  - Wu Y
FAU - Fan, Yunxia
AU  - Fan Y
FAU - Xu, Ming
AU  - Xu M
FAU - Zhang, Jianhua
AU  - Zhang J
LA  - eng
GR  - DA11005/DA/NIDA NIH HHS/United States
GR  - DA13786/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060313
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (RNA, Messenger)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Excitatory Amino Acid Agonists/pharmacology
MH  - Gene Expression/drug effects/*physiology
MH  - Hippocampus/*cytology/metabolism
MH  - Immunohistochemistry/methods
MH  - In Situ Hybridization/methods
MH  - Kainic Acid/pharmacology
MH  - Mice
MH  - Mice, Transgenic
MH  - Neurons/*metabolism
MH  - Proto-Oncogene Proteins c-fos/genetics/*physiology
MH  - RNA, Messenger/genetics/metabolism
EDAT- 2006/03/15 09:00
MHDA- 2006/08/05 09:00
CRDT- 2006/03/15 09:00
PHST- 2006/01/06 00:00 [received]
PHST- 2006/02/15 00:00 [revised]
PHST- 2006/02/16 00:00 [accepted]
PHST- 2006/03/15 09:00 [pubmed]
PHST- 2006/08/05 09:00 [medline]
PHST- 2006/03/15 09:00 [entrez]
AID - S0304-3940(06)00193-5 [pii]
AID - 10.1016/j.neulet.2006.02.063 [doi]
PST - ppublish
SO  - Neurosci Lett. 2006 May 29;400(1-2):177-80. doi: 10.1016/j.neulet.2006.02.063. 
      Epub 2006 Mar 13.