PMID- 16531049
OWN - NLM
STAT- MEDLINE
DCOM- 20060906
LR  - 20131121
IS  - 0969-9961 (Print)
IS  - 0969-9961 (Linking)
VI  - 23
IP  - 1
DP  - 2006 Jul
TI  - Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated 
      with status epilepticus severity: no impact on survival of seizure-generated 
      neurons.
PG  - 23-35
AB  - Partial and generalized status epilepticus (pSE and gSE) trigger the same level 
      of progenitor cell proliferation in adult dentate gyrus, but survival of new 
      neurons is poor after gSE. Here, we show markedly elevated levels of 
      prostaglandin E2 (PGE2) and brain-derived neurotrophic factor (BDNF) in rat 
      hippocampal formation at 7 days following pSE but not gSE. Administration of the 
      cyclooxygenase (COX) inhibitor flurbiprofen for 1 week, starting at day 8 
      post-SE, abated PGE2 and decreased BDNF levels, but did not affect survival of 
      new neurons 4 weeks later. Thus, high PGE2 and BDNF levels induced by pSE are 
      probably not of major importance for survival of new neurons during the first 
      days after formation. We propose that they modulate other aspects of synaptic and 
      cellular plasticity, and thereby may influence epileptogenesis.
FAU - Ajmone-Cat, Maria Antonietta
AU  - Ajmone-Cat MA
AD  - Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale 
      Regina Elena 299, 00161 Rome, Italy. ajcat@iss.it
FAU - Iosif, Robert E
AU  - Iosif RE
FAU - Ekdahl, Christine T
AU  - Ekdahl CT
FAU - Kokaia, Zaal
AU  - Kokaia Z
FAU - Minghetti, Luisa
AU  - Minghetti L
FAU - Lindvall, Olle
AU  - Lindvall O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060313
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 5GRO578KLP (Flurbiprofen)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/drug effects/*metabolism
MH  - Cell Proliferation
MH  - Cell Survival
MH  - Cyclooxygenase Inhibitors/pharmacology
MH  - Dinoprostone/*metabolism
MH  - Flurbiprofen/pharmacology
MH  - Hippocampus/*metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Neuronal Plasticity/*physiology
MH  - Neurons/*cytology/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Seizures/physiopathology
MH  - Status Epilepticus/*physiopathology
MH  - Stem Cells/cytology/metabolism
EDAT- 2006/03/15 09:00
MHDA- 2006/09/07 09:00
CRDT- 2006/03/15 09:00
PHST- 2005/09/10 00:00 [received]
PHST- 2006/01/24 00:00 [revised]
PHST- 2006/01/27 00:00 [accepted]
PHST- 2006/03/15 09:00 [pubmed]
PHST- 2006/09/07 09:00 [medline]
PHST- 2006/03/15 09:00 [entrez]
AID - S0969-9961(06)00016-7 [pii]
AID - 10.1016/j.nbd.2006.01.010 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2006 Jul;23(1):23-35. doi: 10.1016/j.nbd.2006.01.010. Epub 2006 
      Mar 13.