PMID- 16531050
OWN - NLM
STAT- MEDLINE
DCOM- 20060824
LR  - 20131121
IS  - 0969-9961 (Print)
IS  - 0969-9961 (Linking)
VI  - 22
IP  - 3
DP  - 2006 Jun
TI  - Increased slow oscillatory activity in substantia nigra pars reticulata triggers 
      abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of 
      excessive extracellular striatal dopamine.
PG  - 586-98
AB  - Since electrophysiological correlates of L-dopa-induced dyskinesia (LID) are 
      almost unknown, changes of striatal dopamine (DA) transmission and 
      electrophysiological activity of the substantia nigra pars reticulata (SNr) were 
      recorded before and after acute L-dopa administration in sham-operated and 
      6-hydroxydopamine (6-OHDA)-lesioned rats that were previously treated with 
      vehicle or L-dopa for 10 days. Abnormal involuntary movements occurred only in 
      the L-dopa-primed 6-OHDA-lesioned rats that showed after acute l-dopa 
      administration a decrease in firing rate, the highest local field potential power 
      in the theta/alpha band, a consequent oscillatory activity in the same frequency 
      band at the single neuron level and an excessive increase in striatal DA release 
      associated with the lowest level of DA metabolism. These results suggest that 
      increased synchronised afferent activity may drive SNr oscillations in the same 
      frequency band and is associated with abnormal involuntary movements, further 
      suggesting the potential use of desynchronising drugs for managing LID in 
      Parkinson's disease.
FAU - Meissner, Wassilios
AU  - Meissner W
AD  - Laboratoire de Physiologie et Physiopathologie de la Signalisation Cellulaire, 
      CNRS UMR 5543, Universite Victor Segalen, 146 rue Leo Saignat, 33076 Bordeaux 
      Cedex, France.
FAU - Ravenscroft, Paula
AU  - Ravenscroft P
FAU - Reese, Rene
AU  - Reese R
FAU - Harnack, Daniel
AU  - Harnack D
FAU - Morgenstern, Rudolf
AU  - Morgenstern R
FAU - Kupsch, Andreas
AU  - Kupsch A
FAU - Klitgaard, Henrik
AU  - Klitgaard H
FAU - Bioulac, Bernard
AU  - Bioulac B
FAU - Gross, Christian E
AU  - Gross CE
FAU - Bezard, Erwan
AU  - Bezard E
FAU - Boraud, Thomas
AU  - Boraud T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060310
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (Adrenergic Agents)
RN  - 0 (Dopamine Agents)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 46627O600J (Levodopa)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Adrenergic Agents/*toxicity
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Chromatography, High Pressure Liquid
MH  - Corpus Striatum/*chemistry/metabolism
MH  - Dopamine/*metabolism
MH  - Dopamine Agents/metabolism/pharmacology
MH  - Dyskinesias/*etiology/physiopathology
MH  - Extracellular Fluid/chemistry
MH  - Homovanillic Acid/metabolism
MH  - Levodopa/metabolism/pharmacology
MH  - Male
MH  - Membrane Potentials/physiology
MH  - Microdialysis
MH  - Neurons/drug effects/metabolism
MH  - Oxidopamine/*toxicity
MH  - Rats
MH  - Rats, Wistar
MH  - Substantia Nigra/drug effects/*physiopathology
EDAT- 2006/03/15 09:00
MHDA- 2006/08/25 09:00
CRDT- 2006/03/15 09:00
PHST- 2005/11/29 00:00 [received]
PHST- 2006/01/03 00:00 [revised]
PHST- 2006/01/05 00:00 [accepted]
PHST- 2006/03/15 09:00 [pubmed]
PHST- 2006/08/25 09:00 [medline]
PHST- 2006/03/15 09:00 [entrez]
AID - S0969-9961(06)00002-7 [pii]
AID - 10.1016/j.nbd.2006.01.009 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2006 Jun;22(3):586-98. doi: 10.1016/j.nbd.2006.01.009. Epub 2006 
      Mar 10.