PMID- 16532324
OWN - NLM
STAT- MEDLINE
DCOM- 20061024
LR  - 20220408
IS  - 0012-186X (Print)
IS  - 0012-186X (Linking)
VI  - 49
IP  - 5
DP  - 2006 May
TI  - Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA 
      Augsburg study, 1984-2002.
PG  - 921-9
AB  - AIMS/HYPOTHESIS: The chemokines monocyte chemoattractant protein-1 (MCP-1), IL-8 
      and interferon-gamma-inducible protein-10 (IP-10) are released by adipocytes and 
      appear to be involved in atherosclerosis. We hypothesised that these chemokines 
      may be risk factors for the development of type 2 diabetes. SUBJECTS AND METHODS: 
      Using a case-cohort design based on data from the population-based Monitoring of 
      Trends and Determinants in Cardiovascular Disease (MONICA)/Kooperative 
      Gesundheitsforschung in der Region Augsburg/Cooperative Health Research in the 
      Region of Augsburg (KORA Augsburg) study, chemokine levels at baseline were 
      analysed in 526 individuals with and 1,695 individuals without incident type 2 
      diabetes. The mean follow-up time was 10.8 years. RESULTS: MCP-1 was associated 
      with type 2 diabetes, largely independently of classic risk factors, whereas 
      various clinical and metabolic parameters as well as lifestyle factors were major 
      confounders of the association of IL-8 and IP-10 with type 2 diabetes. Further 
      adjustment for C-reactive protein (CRP) and IL-6 had no impact on the observed 
      associations. The hazard ratio (HR) for subjects with systemic concentrations of 
      all three chemokines (MCP-1, IL-8 and IP-10) above the respective median compared 
      with those with all chemokines below or equal to the median was 1.79 (95% CI 
      1.18-2.72) and was comparable with the HR for elevated CRP and IL-6 together 
      (adjusted for age, sex, survey, BMI, systolic blood pressure, total 
      cholesterol:HDL cholesterol ratio, physical activity, alcohol intake, smoking and 
      parental history of diabetes). CONCLUSIONS/INTERPRETATION: Elevated 
      concentrations of MCP-1, IL-8 and IP-10 are associated with incident type 2 
      diabetes. Whereas the association of IL-8 and IP-10 with diabetes was attenuated 
      by multivariable adjustment, high MCP-1 levels contributed to diabetes risk 
      independently of previously described clinical, metabolic and immunological risk 
      factors.
FAU - Herder, C
AU  - Herder C
AD  - German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at Heinrich Heine 
      University, 40225, Dusseldorf, Germany. christian.herder@ddz.uni-duesseldorf.de
FAU - Baumert, J
AU  - Baumert J
FAU - Thorand, B
AU  - Thorand B
FAU - Koenig, W
AU  - Koenig W
FAU - de Jager, W
AU  - de Jager W
FAU - Meisinger, C
AU  - Meisinger C
FAU - Illig, T
AU  - Illig T
FAU - Martin, S
AU  - Martin S
FAU - Kolb, H
AU  - Kolb H
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20060311
PL  - Germany
TA  - Diabetologia
JT  - Diabetologia
JID - 0006777
RN  - 0 (Chemokines)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Body Size
MH  - Cardiovascular Diseases/epidemiology/prevention & control
MH  - Chemokines/*blood
MH  - Cholesterol/blood
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/blood/*epidemiology
MH  - Female
MH  - Germany/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Physiologic
MH  - Prevalence
MH  - Risk Factors
EDAT- 2006/03/15 09:00
MHDA- 2006/10/25 09:00
CRDT- 2006/03/15 09:00
PHST- 2005/07/21 00:00 [received]
PHST- 2005/12/14 00:00 [accepted]
PHST- 2006/03/15 09:00 [pubmed]
PHST- 2006/10/25 09:00 [medline]
PHST- 2006/03/15 09:00 [entrez]
AID - 10.1007/s00125-006-0190-y [doi]
PST - ppublish
SO  - Diabetologia. 2006 May;49(5):921-9. doi: 10.1007/s00125-006-0190-y. Epub 2006 Mar 
      11.