PMID- 16533342
OWN - NLM
STAT- MEDLINE
DCOM- 20060524
LR  - 20111117
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 55
IP  - 4
DP  - 2006 Apr
TI  - Studies on the human leukocyte antigens in patients with polycystic ovary 
      syndrome in a Japanese population--possible susceptibility of HLA-A11 and 
      -DRB1*0403 to patient population with polycystic ovary syndrome.
PG  - 301-6
AB  - PROBLEM: The objective of this study was to identify the human leukocyte antigen 
      (HLA) alleles that confer susceptibility or resistance to polycystic ovary 
      syndrome (PCOS) in the Japanese population. METHOD OF STUDY: HLA-A, -B and -C 
      antigens were determined in 56 patients with PCOS using conventional serological 
      method. HLA-DRB1 genotypes were determined using a polymerase chain 
      reaction-restriction fragment length polymorphism (PCR-RFLP) method in 68 
      patients with PCOS. As a control population, 237 healthy individuals (males and 
      females) were examined concerning HLA-A, -B and -C antigens, and 292 individuals 
      were examined concerning HLA-DRB1 genotypes. The rate of possession of each 
      antigen was compared between the two populations. RESULTS: The rate of possession 
      of the HLA-A11 and HLA-DRB1*0403 in the patients with PCOS was significantly 
      higher compared with that in the control group. The rate of possession of HLA-B39 
      in the patients with PCOS was significantly lower compared with that in the 
      general population group. CONCLUSION: Human leukocyte antigen systems appear to 
      be linked to PCOS.
FAU - Kaibe, Mamiko
AU  - Kaibe M
AD  - Department of Obstetrics and Gynecology, Niigata University School of Medicine, 
      Niigata, Japan.
FAU - Takakuwa, Koichi
AU  - Takakuwa K
FAU - Murakawa, Haruo
AU  - Murakawa H
FAU - Ishii, Keisuke
AU  - Ishii K
FAU - Tamura, Masaki
AU  - Tamura M
FAU - Tanaka, Kenichi
AU  - Tanaka K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A11 Antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B39 Antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-A Antigens/*genetics
MH  - HLA-A11 Antigen
MH  - HLA-B Antigens/genetics
MH  - HLA-B39 Antigen
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Japan
MH  - Polycystic Ovary Syndrome/*genetics/*immunology
EDAT- 2006/03/15 09:00
MHDA- 2006/05/25 09:00
CRDT- 2006/03/15 09:00
PHST- 2006/03/15 09:00 [pubmed]
PHST- 2006/05/25 09:00 [medline]
PHST- 2006/03/15 09:00 [entrez]
AID - AJI369 [pii]
AID - 10.1111/j.1600-0897.2006.00369.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2006 Apr;55(4):301-6. doi: 10.1111/j.1600-0897.2006.00369.x.