PMID- 16533499
OWN - NLM
STAT- MEDLINE
DCOM- 20061107
LR  - 20220408
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 60
IP  - 7
DP  - 2006 Oct 1
TI  - Early social enrichment shapes social behavior and nerve growth factor and 
      brain-derived neurotrophic factor levels in the adult mouse brain.
PG  - 690-6
AB  - BACKGROUND: Early experiences produce persistent changes in brain and behavioral 
      function. We investigate whether being reared in a communal nest (CN), a form of 
      early social enrichment that characterizes the natural ecological niche of many 
      rodent species including the mouse, has effects on adult social/aggressive 
      behavior and nerve growth factor (NGF) and brain-derived neurotrophic factor 
      (BDNF) levels in mice. METHODS: The CN consisted of a single nest where three 
      mothers kept their pups together and shared care-giving behavior from birth to 
      weaning (postnatal day 25). RESULTS: Compared to standard laboratory conditions, 
      in CN condition, mouse mothers displayed higher levels of maternal care. At 
      adulthood, CN mice displayed higher propensity to interact socially and achieved 
      more promptly the behavioral profile of either dominant or subordinate male. 
      Furthermore, CN adult mice showed higher NGF levels, which were further affected 
      by social status, and higher BDNF levels in the brain. CONCLUSIONS: Our findings 
      indicate that CN, a highly stimulating early social environment, produces 
      differences in social behavior later in life associated with marked changes of 
      neurotrophin levels in selected brain areas, including hippocampus and 
      hypothalamus.
FAU - Branchi, Igor
AU  - Branchi I
AD  - Department of Cell Biology and Neuroscience, Section of Behavioural 
      Neurosciences, Istituto Superiore di Sanita, Viale Regian Elena 299, I-00161 
      Roma, Rome, Italy. branchi@iss.it
FAU - D'Andrea, Ivana
AU  - D'Andrea I
FAU - Fiore, Marco
AU  - Fiore M
FAU - Di Fausto, Veronica
AU  - Di Fausto V
FAU - Aloe, Luigi
AU  - Aloe L
FAU - Alleva, Enrico
AU  - Alleva E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060314
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Age Factors
MH  - Aggression/physiology
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Female
MH  - Male
MH  - Maternal Behavior/physiology
MH  - Mice
MH  - Nerve Growth Factor/*metabolism
MH  - *Social Behavior
MH  - *Social Environment
EDAT- 2006/03/15 09:00
MHDA- 2006/11/09 09:00
CRDT- 2006/03/15 09:00
PHST- 2005/10/07 00:00 [received]
PHST- 2006/01/02 00:00 [revised]
PHST- 2006/01/03 00:00 [accepted]
PHST- 2006/03/15 09:00 [pubmed]
PHST- 2006/11/09 09:00 [medline]
PHST- 2006/03/15 09:00 [entrez]
AID - S0006-3223(06)00101-6 [pii]
AID - 10.1016/j.biopsych.2006.01.005 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2006 Oct 1;60(7):690-6. doi: 10.1016/j.biopsych.2006.01.005. 
      Epub 2006 Mar 14.