PMID- 16533555
OWN - NLM
STAT- MEDLINE
DCOM- 20070424
LR  - 20060711
IS  - 0303-2647 (Print)
IS  - 0303-2647 (Linking)
VI  - 85
IP  - 2
DP  - 2006 Aug
TI  - The origin of spontaneous synchronized burst in cultured neuronal networks based 
      on multi-electrode arrays.
PG  - 137-43
AB  - Many neural networks in mammalian central nervous system (CNS) fire single spike 
      and complex spike burst. In fact, the conditions for triggering burst are not 
      well understood. In the paper multi-electrode arrays (MEA) are used to record the 
      spontaneous electrophysiological activities of cultured rat hippocampal neuronal 
      network for a long time. After about 3 weeks culture, a transition from single 
      spike to burst is observed in several networks. All of these spikes fire quickly 
      before burst begins. The firing rate during the burst is lower than that just 
      before the burst, but differences of inter-spike intervals (ISIs) between two 
      firing patterns are not clear. Moreover, the electrical activities on neighboring 
      electrodes show strong synchrony during the burst activities. In a word, the 
      generation of the burst requires that network should have a sufficient level of 
      excitation as well as a balance of synaptic inhibition.
FAU - Chen, Chuanping
AU  - Chen C
AD  - Key Laboratory of Biomedical Photonics, Ministry of Education, Huazhong 
      University of Science and Technology, Wuhan 430074, China. chchuanp2002@etang.com
FAU - Chen, Lin
AU  - Chen L
FAU - Lin, Yunsheng
AU  - Lin Y
FAU - Zeng, Shaoqun
AU  - Zeng S
FAU - Luo, Qingming
AU  - Luo Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060314
PL  - Ireland
TA  - Biosystems
JT  - Bio Systems
JID - 0430773
SB  - IM
MH  - Animals
MH  - Electrodes
MH  - Electrophysiology
MH  - Nerve Net/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Substrate Specificity
MH  - Tissue Culture Techniques
EDAT- 2006/03/15 09:00
MHDA- 2007/04/25 09:00
CRDT- 2006/03/15 09:00
PHST- 2005/09/23 00:00 [received]
PHST- 2005/12/22 00:00 [revised]
PHST- 2005/12/27 00:00 [accepted]
PHST- 2006/03/15 09:00 [pubmed]
PHST- 2007/04/25 09:00 [medline]
PHST- 2006/03/15 09:00 [entrez]
AID - S0303-2647(05)00213-3 [pii]
AID - 10.1016/j.biosystems.2005.12.006 [doi]
PST - ppublish
SO  - Biosystems. 2006 Aug;85(2):137-43. doi: 10.1016/j.biosystems.2005.12.006. Epub 
      2006 Mar 14.