PMID- 16534530
OWN - NLM
STAT- MEDLINE
DCOM- 20070604
LR  - 20220408
IS  - 0307-0565 (Print)
IS  - 0307-0565 (Linking)
VI  - 30
IP  - 9
DP  - 2006 Sep
TI  - Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and 
      associated with obesity-related parameters.
PG  - 1347-55
AB  - BACKGROUND: Chemotactic cytokines, referred to as chemokines, play an important 
      role in leukocyte trafficking. The circulating levels of chemokines have been 
      shown to increase in inflammatory processes including obesity-related pathologies 
      (e.g. atherosclerosis and diabetes). However, little is currently known about the 
      relationship between chemokines and human obesity. In the present study, we 
      investigated the circulating levels of selected chemokines (monocyte 
      chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1alpha 
      (MIP-1alpha), leukotactin-1, interleukin-8 (IL-8)) and the association between 
      the chemokine levels and obesity-related parameters: body mass index (BMI), waist 
      circumference, fasting glucose and insulin levels, lipids profile, and the level 
      of C-reactive protein (CRP). METHODS: A total of 100 subjects, 50 obese 
      (BMI>or=25 kg/m2) and 50 who were not obese (BMI<25 kg/m2) participated in the 
      present study. The levels of chemokines and CRP were measured in a fasting state 
      serum by sandwich enzyme-linked immunosorbent assay. Total cholesterol, 
      high-density lipoprotein (HDL)-cholesterol, triglyceride, glucose, and insulin 
      levels were measured by enzymatic analysis and immunoassay. RESULTS: The 
      circulating levels of MCP-1 and IL-8 in the serum were significantly (P<0.05) 
      higher in obese subjects (BMI>30 kg/m2) compared with those of nonobese controls 
      (BMI<25 kg/m2). The levels of CRP were positively correlated with BMI (P<0.001) 
      or waist circumference (P<0.0001). The levels of MCP-1 and IL-8 were positively 
      related to BMI (MCP-1, P<0.02; IL-8, P<0.01) and/or waist circumference (MCP-1, 
      P<0.009; IL-8, P<0.03). The levels of MCP-1 were positively related to the levels 
      of CRP (P<0.007) or interleukin-6 (IL-6) (P<0.0001), and negatively related to 
      the levels of HDL-cholesterol (P<0.01). Homeostasis model assessment (HOMA) score 
      was positively related to the levels of MCP-1 (P<0.02) or IL-8 (P<0.03) in obese 
      subject. DISCUSSION: Our data demonstrated that the circulating levels of MCP-1 
      and IL-8 are related to obesity-related parameters such as BMI, waist 
      circumference, CRP, IL-6, HOMA and HDL-cholesterol. These findings suggest that 
      the circulating MCP-1 and/or IL-8 may be a potential candidate linking obesity 
      with obesity-related metabolic complications such as atherosclerosis and 
      diabetes.
FAU - Kim, C-S
AU  - Kim CS
AD  - Department of Food Science and Nutrition, University of Ulsan, Ulsan, Korea.
FAU - Park, H-S
AU  - Park HS
FAU - Kawada, T
AU  - Kawada T
FAU - Kim, J-H
AU  - Kim JH
FAU - Lim, D
AU  - Lim D
FAU - Hubbard, N E
AU  - Hubbard NE
FAU - Kwon, B-S
AU  - Kwon BS
FAU - Erickson, K L
AU  - Erickson KL
FAU - Yu, R
AU  - Yu R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060314
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Interleukin-8)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - C-Reactive Protein/metabolism
MH  - Chemokine CCL2/*blood
MH  - Cholesterol, HDL/blood
MH  - Female
MH  - Humans
MH  - Interleukin-8/*blood
MH  - Male
MH  - Obesity/*blood
MH  - Waist-Hip Ratio
EDAT- 2006/03/15 09:00
MHDA- 2007/06/05 09:00
CRDT- 2006/03/15 09:00
PHST- 2006/03/15 09:00 [pubmed]
PHST- 2007/06/05 09:00 [medline]
PHST- 2006/03/15 09:00 [entrez]
AID - 0803259 [pii]
AID - 10.1038/sj.ijo.0803259 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2006 Sep;30(9):1347-55. doi: 10.1038/sj.ijo.0803259. Epub 2006 
      Mar 14.