PMID- 16536918
OWN - NLM
STAT- MEDLINE
DCOM- 20060425
LR  - 20131121
IS  - 0004-5632 (Print)
IS  - 0004-5632 (Linking)
VI  - 43
IP  - Pt 2
DP  - 2006 Mar
TI  - Plasma gastrin measurement cannot be used to diagnose a gastrinoma in patients on 
      either proton pump inhibitors or histamine type-2 receptor antagonists.
PG  - 153-5
AB  - BACKGROUND: Patients with a gastrinoma are treated with proton pump inhibitors 
      (PPI) and histamine type-2 receptor antagonists (H2). In order to diagnose a 
      gastrinoma these drugs must be discontinued, but this increases the risk of 
      gastrointestinal perforation. We aimed to determine if a gastrinoma could be 
      diagnosed without cessation of PPI/H2 therapy. METHODS: In all, 90 patients 
      (controls and patients diagnosed with a gastrinoma both on and off PPI/H2 
      therapy) were recruited, and plasma gastrin measured. RESULTS: Patients with a 
      gastrinoma on PPI/H2 medication had a significantly higher fasting plasma gastrin 
      concentration than control patients on PPI/H2 medication (298+/-33 versus 
      204+/-30 pmol/L, P = 0.01). However, there was substantial overlap between 
      gastrin levels in these two groups. CONCLUSION: This study confirms that a 
      gastrinoma cannot be diagnosed on the basis of a fasting plasma gastrin assay 
      while patients remain on PPI/H2 therapy.
FAU - Dhillo, W S
AU  - Dhillo WS
AD  - Department of Endocrinology, Imperial College Faculty of Medicine, Hammersmith 
      Hospital, London W12 ONN, UK.
FAU - Jayasena, C N
AU  - Jayasena CN
FAU - Lewis, C J
AU  - Lewis CJ
FAU - Martin, N M
AU  - Martin NM
FAU - Tang, K C N
AU  - Tang KC
FAU - Meeran, K
AU  - Meeran K
FAU - Todd, J F
AU  - Todd JF
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Clin Biochem
JT  - Annals of clinical biochemistry
JID - 0324055
RN  - 0 (Gastrins)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Female
MH  - Gastrinoma/*diagnosis/drug therapy
MH  - Gastrins/*blood
MH  - Histamine H2 Antagonists/administration & dosage/*therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pancreatic Neoplasms/*diagnosis/drug therapy
MH  - *Proton Pump Inhibitors
EDAT- 2006/03/16 09:00
MHDA- 2006/04/28 09:00
CRDT- 2006/03/16 09:00
PHST- 2006/03/16 09:00 [pubmed]
PHST- 2006/04/28 09:00 [medline]
PHST- 2006/03/16 09:00 [entrez]
AID - 10.1258/000456306776021607 [doi]
PST - ppublish
SO  - Ann Clin Biochem. 2006 Mar;43(Pt 2):153-5. doi: 10.1258/000456306776021607.