PMID- 16541456
OWN - NLM
STAT- MEDLINE
DCOM- 20061114
LR  - 20221207
IS  - 0885-3185 (Print)
IS  - 0885-3185 (Linking)
VI  - 21
IP  - 6
DP  - 2006 Jun
TI  - Brain-derived neurotrophic factor: a genetic risk factor for obsessive-compulsive 
      disorder and Tourette syndrome?
PG  - 881-3
AB  - A strong association of the G196A polymorphism of the brain-derived neurotrophic 
      factor (BDNF) gene with obsessive-compulsive disorder (OCD) has been reported. 
      Patients with Gilles de la Tourette's syndrome (GTS) often develop OCD as well, 
      suggesting a shared genetic susceptibility for OCD and GTS. We investigated 
      whether BNDF is associated not only with OCD but also with GTS. The G196A 
      polymorphism of the BNDF gene was genotyped in 88 GTS trios. The extended 
      transmission/disequilibrium test was applied. The transmission rates for both 
      alleles did not differ from the expected transmission rates. This finding 
      suggests that GTS and OCD may have distinct genetic risk factors.
FAU - Klaffke, Stefanie
AU  - Klaffke S
AD  - Academic Neurology Unit, Division of Genomic Medicine, University of Sheffield, 
      United Kingdom.
FAU - Konig, Inke R
AU  - Konig IR
FAU - Poustka, Fritz
AU  - Poustka F
FAU - Ziegler, Andreas
AU  - Ziegler A
FAU - Hebebrand, Johannes
AU  - Hebebrand J
FAU - Bandmann, Oliver
AU  - Bandmann O
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mov Disord
JT  - Movement disorders : official journal of the Movement Disorder Society
JID - 8610688
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9007-49-2 (DNA)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Amino Acid Substitution
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - DNA/blood/isolation & purification
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Methionine
MH  - Obsessive-Compulsive Disorder/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Tourette Syndrome/*genetics
MH  - Valine
MH  - White People/genetics
EDAT- 2006/03/17 09:00
MHDA- 2006/11/15 09:00
CRDT- 2006/03/17 09:00
PHST- 2006/03/17 09:00 [pubmed]
PHST- 2006/11/15 09:00 [medline]
PHST- 2006/03/17 09:00 [entrez]
AID - 10.1002/mds.20849 [doi]
PST - ppublish
SO  - Mov Disord. 2006 Jun;21(6):881-3. doi: 10.1002/mds.20849.