PMID- 16541963
OWN - NLM
STAT- MEDLINE
DCOM- 20060801
LR  - 20161020
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 26
IP  - 6
DP  - 2005 Nov-Dec
TI  - Epidemiology and pathophysiology of immunoglobulin E-mediated asthma.
PG  - 423-7
AB  - Asthma is one of the most common chronic conditions affecting mankind. The 
      development of asthma may at least in part result from genetic or host 
      susceptibility to asthma, allergy or atopy, and bronchial hyperresponsiveness. 
      The interaction between the at risk host and environmental exposures to 
      allergens, air pollutants, and viral infections may lead to the development of 
      asthma. Much is mentioned about the hygiene hypothesis as a possible reason for 
      the increased in atopy conditions such as asthma in developed countries 
      throughout the world. With the discovery of immunoglobulin E (IgE), the medical 
      community has learned the importance of this immunoglobulin in all atopic 
      conditions, especially asthma. Recent literature in peer-reviewed journals on 
      serum IgE and asthma was examined. Numerous studies clearly show the relationship 
      of asthma to specific allergens, but only recently has there been documentation 
      of the association of total serum IgE level with airways hyperreactivity and 
      asthma. Data on patients with severe or difficult-to-treat asthma showed serum 
      IgE levels higher in asthmatic patients than in nonasthmatic patients and the 
      more severe the asthma, the higher the serum IgE. Our increasing knowledge of the 
      underlying role of IgE in the asthmatic patient should pave the way for better 
      treatments for this population of sufferers.
FAU - Blaiss, Michael S
AU  - Blaiss MS
AD  - Department of Pediatrics and Medicine, University of Tennessee, Memphis, TN, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/epidemiology/*immunology/physiopathology/therapy
MH  - Bronchial Hyperreactivity/immunology
MH  - Humans
MH  - Hypersensitivity, Immediate/epidemiology/physiopathology
MH  - Immunoglobulin E/*blood
RF  - 22
EDAT- 2006/03/18 09:00
MHDA- 2006/08/02 09:00
CRDT- 2006/03/18 09:00
PHST- 2006/03/18 09:00 [pubmed]
PHST- 2006/08/02 09:00 [medline]
PHST- 2006/03/18 09:00 [entrez]
PST - ppublish
SO  - Allergy Asthma Proc. 2005 Nov-Dec;26(6):423-7.