PMID- 16542160
OWN - NLM
STAT- MEDLINE
DCOM- 20060518
LR  - 20161124
IS  - 0001-6314 (Print)
IS  - 0001-6314 (Linking)
VI  - 113
IP  - 4
DP  - 2006 Apr
TI  - Cardiovascular dysautonomia in Parkinson's disease and multiple system atrophy.
PG  - 221-7
AB  - OBJECTIVES: To determine whether Parkinson's disease (PD) can be distinguished 
      from multiple system atrophy (MSA) on the basis of the assessment of iodine-123 
      meta-iodobenzylguanidine (123I-MIBG) radioactivity in heart and cardiovascular 
      autonomic function. PATIENTS AND METHODS: Seventeen patients with MSA, 39 with 
      PD, and 25 healthy volunteers underwent 123I-MIBG scintigraphy and hemodynamic 
      autonomic function tests using Valsalva maneuver (VM). Baroreceptor reflex 
      sensitivity (BRS) was measured using the slope of the relation between RR 
      interval and blood pressure during the fourth phase. RESULTS: 123I-MIBG 
      radioactivity in heart of patients with PD was lower than that of control 
      subjects and patients with MSA, but there was some overlap between PD and MSA. 
      BRS in patients with PD who had a 123I-MIBG radioactivity similar to that in MSA 
      was larger than that in patients with MSA, with no overlap in any patient. 
      CONCLUSION: Assessment of BRS may be useful for differentiating between MSA and 
      PD that had a 123I-MIBG radioactivity similar to MSA.
FAU - Oka, H
AU  - Oka H
AD  - Department of Neurology, Aoto Hospital, Tokyo, Japan. h.oka@jikei.ac.jp
FAU - Mochio, S
AU  - Mochio S
FAU - Yoshioka, M
AU  - Yoshioka M
FAU - Morita, M
AU  - Morita M
FAU - Onouchi, K
AU  - Onouchi K
FAU - Inoue, K
AU  - Inoue K
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Radiopharmaceuticals)
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
SB  - IM
RIN - Oka H, Mochio S, Yoshioka M, Morita M, Onouchi K, Inoue K. Acta Neurol Scand. 
      2008 Sep;118(3):208. PMID: 18803758
RIN - Ben-Menachem E, Wikkelso C. Acta Neurol Scand. 2008 Sep;118(3):208. PMID: 
      19034988
MH  - 3-Iodobenzylguanidine
MH  - Aged
MH  - Autonomic Nervous System/diagnostic imaging/*physiopathology
MH  - Baroreflex/physiology
MH  - Cardiovascular System/diagnostic imaging/*innervation/physiopathology
MH  - Case-Control Studies
MH  - Humans
MH  - Iodine Radioisotopes
MH  - Middle Aged
MH  - Multiple System Atrophy/*diagnostic imaging/*physiopathology
MH  - Parkinson Disease/*diagnostic imaging/*physiopathology
MH  - Radionuclide Imaging
MH  - Radiopharmaceuticals
MH  - Valsalva Maneuver
EDAT- 2006/03/18 09:00
MHDA- 2006/05/19 09:00
CRDT- 2006/03/18 09:00
PHST- 2006/03/18 09:00 [pubmed]
PHST- 2006/05/19 09:00 [medline]
PHST- 2006/03/18 09:00 [entrez]
AID - ANE526 [pii]
AID - 10.1111/j.1600-0404.2005.00526.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2006 Apr;113(4):221-7. doi: 10.1111/j.1600-0404.2005.00526.x.