PMID- 16543631
OWN - NLM
STAT- MEDLINE
DCOM- 20060705
LR  - 20061115
IS  - 1386-0291 (Print)
IS  - 1386-0291 (Linking)
VI  - 34
IP  - 1-2
DP  - 2006
TI  - Activated protein C stimulates expression of angiogenic factors in human skin 
      cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents.
PG  - 153-61
AB  - Activated protein C (APC) is a serine protease that plays a central role in 
      physiological anticoagulation, and has more recently been shown to be a potent 
      anti-inflammatory mediator. We show here that APC upregulates the angiogenic 
      promoters, vascular endothelial growth factor (VEGF), monocyte chemoattractant 
      protein-1 (MCP-1), interleukin-8 (IL-8) or matrix metalloproteinase-2 (MMP-2) in 
      cultured human skin fibroblasts (HF), keratinocytes (HK) or umbilical vein 
      endothelial cells (HUVE). In the chick embryo chorio-allantoic membrane assay, 
      APC promoted angiogenesis. In a full-thickness rat skin healing model, a single 
      topical application of APC enhanced wound healing compared to saline control. In 
      summary, our results demonstrate that APC promotes cutaneous wound healing at 
      least partly by stimulation of angiogenesis.
FAU - Xue, Meilang
AU  - Xue M
AD  - Sutton Arthritis Research Laboratories, Institute of Bone and Joint Research, 
      University of Sydney, NSW, Australia.
FAU - Thompson, Patrick
AU  - Thompson P
FAU - Sambrook, Philip N
AU  - Sambrook PN
FAU - March, Lyn
AU  - March L
FAU - Jackson, Christopher J
AU  - Jackson CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Hemorheol Microcirc
JT  - Clinical hemorheology and microcirculation
JID - 9709206
RN  - 0 (Angiogenic Proteins)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
RN  - 0 (Protein C)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
SB  - IM
MH  - Angiogenic Proteins/*genetics
MH  - Animals
MH  - Chemokine CCL2/genetics
MH  - Chick Embryo
MH  - Humans
MH  - Interleukin-8/genetics
MH  - Matrix Metalloproteinase 2/genetics
MH  - *Neovascularization, Physiologic
MH  - Protein C/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Skin/*cytology
MH  - Up-Regulation/drug effects
MH  - Vascular Endothelial Growth Factor A/genetics
MH  - Wound Healing/drug effects
EDAT- 2006/03/18 09:00
MHDA- 2006/07/06 09:00
CRDT- 2006/03/18 09:00
PHST- 2006/03/18 09:00 [pubmed]
PHST- 2006/07/06 09:00 [medline]
PHST- 2006/03/18 09:00 [entrez]
PST - ppublish
SO  - Clin Hemorheol Microcirc. 2006;34(1-2):153-61.