PMID- 1654381
OWN - NLM
STAT- MEDLINE
DCOM- 19911018
LR  - 20061115
IS  - 0022-1317 (Print)
IS  - 0022-1317 (Linking)
VI  - 72 ( Pt 9)
DP  - 1991 Sep
TI  - The unique region of the human herpesvirus 6 genome is essentially collinear with 
      the UL segment of human cytomegalovirus.
PG  - 2293-7
AB  - The entire genome of human herpesvirus 6 (HHV-6) strain U1102 was cloned as 
      overlapping fragments in cosmid and plasmid vectors. Cleavage maps were 
      constructed for the restriction endonucleases BamHI, EcoRI, NotI and SmaI. The 
      genome of HHV-6 U1102 is a linear dsDNA of 163 kbp, consisting of a long unique 
      142 kbp region flanked by direct terminal repeats of 10.5 kbp. Short stretches 
      (290 to 470 nucleotides) of DNA, four from the terminal repeats and 55 from the 
      UL region, were sequenced and compared by computer with the known herpesvirus 
      amino acid sequences. Homologies were found for 10 open reading frames that are 
      scattered over the UL region of HHV-6. Their relative positions and orientations 
      indicate that the unique region of HHV-6 is essentially collinear with the UL 
      region of human cytomegalovirus (HCMV), but is not collinear with the other human 
      herpesviruses. It confirms and extends earlier observations that HHV-6 is more 
      closely related to the beta-herpesvirus HCMV, suggesting that HHV-6 may be 
      considered as the prototype of a new beta 2-herpesvirus subgroup.
FAU - Neipel, F
AU  - Neipel F
AD  - Institut fur Klinische und Molekulare Virologie, Universitat Erlangen-Nurnberg, 
      Germany.
FAU - Ellinger, K
AU  - Ellinger K
FAU - Fleckenstein, B
AU  - Fleckenstein B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Cloning, Molecular
MH  - Cosmids
MH  - Cytomegalovirus/classification/*genetics
MH  - DNA, Viral/analysis
MH  - Herpesvirus 6, Human/classification/*genetics
MH  - Humans
MH  - Restriction Mapping
MH  - Sequence Homology, Nucleic Acid
EDAT- 1991/09/01 00:00
MHDA- 1991/09/01 00:01
CRDT- 1991/09/01 00:00
PHST- 1991/09/01 00:00 [pubmed]
PHST- 1991/09/01 00:01 [medline]
PHST- 1991/09/01 00:00 [entrez]
AID - 10.1099/0022-1317-72-9-2293 [doi]
PST - ppublish
SO  - J Gen Virol. 1991 Sep;72 ( Pt 9):2293-7. doi: 10.1099/0022-1317-72-9-2293.