PMID- 1654455
OWN - NLM
STAT- MEDLINE
DCOM- 19911022
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 65
IP  - 10
DP  - 1991 Oct
TI  - Identification of the human herpesvirus 6 glycoprotein H and putative large 
      tegument protein genes.
PG  - 5597-604
AB  - Determination of the nucleotide sequences of two molecular clones of human 
      herpesvirus 6 (HHV-6) (strain GS) and comparison with those of human 
      cytomegalovirus (HCMV) has allowed the identification of the genes for the 
      glycoprotein H (gH) and the putative large tegument protein of HHV-6. Two 
      molecular clones of fragments of HHV-6, the BamHI-G fragment (7,981 bp) of the 
      clone termed pZVB43 and a HindIII fragment (8,717 bp) of the clone termed pZVH14, 
      represent approximately 10% of the HHV-6 genome (16,689). An open reading frame 
      within the BamHI-G fragment was designated the gH gene of HHV-6 because of the 
      extensive sequence similarity of its predicted product (79,549 Da) to the HCMV gH 
      gene product. The predicted product (239,589 Da) of an open reading frame within 
      clone pZVH14 showed homology to the predicted product of the proposed gene of 
      HCMV representing the large tegument protein. Computer analyses indicated a 
      closer relationship of the predicted peptides of these HHV-6 genes to those of 
      HCMV than to those of the other human herpesviruses Epstein-Barr virus, herpes 
      simplex virus type 1, and varicella-zoster virus. The gH gene was more conserved 
      among the human herpesvirus group, while significant sequence similarity of the 
      tegument gene could be found only with that of HCMV. The data reported here with 
      one conserved gene (gH) and a more divergent gene (tegument) support previous 
      reports that HHV-6 and HCMV are more closely related to each other than to the 
      other well-characterized human herpesviruses.
FAU - Josephs, S F
AU  - Josephs SF
AD  - Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 
      20892.
FAU - Ablashi, D V
AU  - Ablashi DV
FAU - Salahuddin, S Z
AU  - Salahuddin SZ
FAU - Jagodzinski, L L
AU  - Jagodzinski LL
FAU - Wong-Staal, F
AU  - Wong-Staal F
FAU - Gallo, R C
AU  - Gallo RC
LA  - eng
SI  - GENBANK/M64578
SI  - GENBANK/M64579
SI  - GENBANK/M64580
SI  - GENBANK/M64581
SI  - GENBANK/M64582
SI  - GENBANK/M64583
SI  - GENBANK/S57426
SI  - GENBANK/S57427
SI  - GENBANK/S57509
SI  - GENBANK/S57540
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Codon)
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (Viral Matrix Proteins)
RN  - 0 (Viral Structural Proteins)
RN  - 0 (cytomegalovirus matrix protein, pp 64-69)
RN  - 142985-75-9 (glycoprotein H, herpesvirus 6)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/microbiology
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - Codon/genetics
MH  - Cytomegalovirus/genetics
MH  - *Genes, Viral
MH  - Herpesvirus 6, Human/*genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Protein Conformation
MH  - Restriction Mapping
MH  - Sequence Homology, Nucleic Acid
MH  - Viral Envelope Proteins/*genetics
MH  - Viral Matrix Proteins/*genetics
MH  - Viral Structural Proteins/*genetics
PMC - PMC249074
EDAT- 1991/10/01 00:00
MHDA- 1991/10/01 00:01
PMCR- 1991/10/01
CRDT- 1991/10/01 00:00
PHST- 1991/10/01 00:00 [pubmed]
PHST- 1991/10/01 00:01 [medline]
PHST- 1991/10/01 00:00 [entrez]
PHST- 1991/10/01 00:00 [pmc-release]
AID - 10.1128/JVI.65.10.5597-5604.1991 [doi]
PST - ppublish
SO  - J Virol. 1991 Oct;65(10):5597-604. doi: 10.1128/JVI.65.10.5597-5604.1991.