PMID- 16546213
OWN - NLM
STAT- MEDLINE
DCOM- 20070206
LR  - 20220409
IS  - 0022-3956 (Print)
IS  - 0022-3956 (Linking)
VI  - 41
IP  - 1-2
DP  - 2007 Jan-Feb
TI  - Reduced serum BDNF levels in schizophrenic patients on clozapine or typical 
      antipsychotics.
PG  - 31-5
AB  - Neurotrophic factors regulate neuronal development and synaptic plasticity, 
      possibly playing a role in the pathophysiology of schizophrenia and other 
      psychiatric disorders. Decreased brain-derived neurotrophic factor (BDNF) levels 
      have been found in brains and in the serum of schizophrenic patients, but results 
      are inconsistent. Also, clozapine may upregulate brain BDNF expression. In the 
      present study, we assessed serum BDNF immunoreactivity in 44 schizophrenic 
      patients (20 on clozapine and 24 on typical antipsychotics) and in 25 healthy 
      volunteers. Serum BDNF levels were measured using an enzyme immunoassay. Healthy 
      controls showed significantly higher levels of BDNF compared to the whole group 
      of schizophrenic patients (p<0.001) as well as to the subgroups on typical 
      antipsychotics and clozapine (p<0.001). Serum BDNF values for controls were 
      168.8+/-26.3pg/ml, for the clozapine group were 125.4+/-44.5pg/ml and for the 
      group on typicals were 101.3+/-51.6pg/ml. BDNF values from patients on clozapine 
      were non-significantly higher than values from patients on typical antipsychotics 
      (p=0.09). Serum BDNF was strongly and positively correlated with clozapine dose 
      (r=0.643; p=0.002) but not with other demographic characteristics. These results 
      reinforce previous findings of reduced serum BDNF levels in schizophrenic 
      patients and suggest a differential effect of clozapine compared to typical 
      antipsychotics on such levels.
FAU - Grillo, Rodrigo W
AU  - Grillo RW
AD  - Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre, Brazil.
FAU - Ottoni, Gustavo L
AU  - Ottoni GL
FAU - Leke, Renata
AU  - Leke R
FAU - Souza, Diogo O
AU  - Souza DO
FAU - Portela, Luiz V
AU  - Portela LV
FAU - Lara, Diogo R
AU  - Lara DR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060320
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - J60AR2IKIC (Clozapine)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*pharmacology/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood/*drug effects
MH  - Clozapine/*pharmacology/*therapeutic use
MH  - Drug Administration Schedule
MH  - Female
MH  - Humans
MH  - Male
MH  - *Schizophrenia/blood/drug therapy/physiopathology
MH  - Synapses/metabolism
EDAT- 2006/03/21 09:00
MHDA- 2007/02/07 09:00
CRDT- 2006/03/21 09:00
PHST- 2005/09/05 00:00 [received]
PHST- 2005/12/16 00:00 [revised]
PHST- 2006/01/12 00:00 [accepted]
PHST- 2006/03/21 09:00 [pubmed]
PHST- 2007/02/07 09:00 [medline]
PHST- 2006/03/21 09:00 [entrez]
AID - S0022-3956(06)00017-3 [pii]
AID - 10.1016/j.jpsychires.2006.01.005 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2007 Jan-Feb;41(1-2):31-5. doi: 
      10.1016/j.jpsychires.2006.01.005. Epub 2006 Mar 20.