PMID- 16546389
OWN - NLM
STAT- MEDLINE
DCOM- 20060706
LR  - 20091119
IS  - 0967-5868 (Print)
IS  - 0967-5868 (Linking)
VI  - 13
IP  - 3
DP  - 2006 Apr
TI  - MuSK antibody-positive, seronegative myasthenia gravis in Korea.
PG  - 353-5
AB  - Several reports from Western countries suggest differences in the clinical 
      features of patients with muscle specific kinase (MuSK) antibody-positive and 
      -negative seronegative myasthenia gravis (MG). We performed the first survey in 
      Korea of MuSK antibodies, studying 23 patients with acetylcholine receptor 
      (AChR)-antibody seronegative MG. MuSK antibodies were present in 4 (26.7%) of 15 
      generalized seronegative MG patients and none of 8 ocular seronegative MG 
      patients. All four MuSK positive patients were females, with pharyngeal and 
      respiratory muscle weakness, and required immunosuppressive treatment. However, 
      overall disease severity and age at onset was similar to that of MuSK-negative MG 
      and treatment responses were equally good.
FAU - Lee, Jee-Young
AU  - Lee JY
AD  - Department of Neurology, Seoul National University Hospital, College of Medicine, 
      Seoul National University 28, Yeongun-dong, Jongno-gu 110-744, Seoul, Korea.
FAU - Sung, Jung Joon
AU  - Sung JJ
FAU - Cho, Joong-Yang
AU  - Cho JY
FAU - Oh, Dong-Hoon
AU  - Oh DH
FAU - Kim, Hyun-Jung
AU  - Kim HJ
FAU - Park, Jong-Ha
AU  - Park JH
FAU - Lee, Kwang Woo
AU  - Lee KW
FAU - Choi, Young-Chul
AU  - Choi YC
FAU - Vincent, Angela
AU  - Vincent A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20060320
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0 (Antibodies)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Receptors, Cholinergic)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Antibodies/*blood
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/pharmacology
MH  - Infant
MH  - Korea/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Myasthenia Gravis/*blood/*immunology/therapy
MH  - Receptor Protein-Tyrosine Kinases/*immunology
MH  - Receptors, Cholinergic/*immunology
MH  - Severity of Illness Index
MH  - Thymectomy/methods
EDAT- 2006/03/21 09:00
MHDA- 2006/07/11 09:00
CRDT- 2006/03/21 09:00
PHST- 2005/03/21 00:00 [received]
PHST- 2005/04/18 00:00 [accepted]
PHST- 2006/03/21 09:00 [pubmed]
PHST- 2006/07/11 09:00 [medline]
PHST- 2006/03/21 09:00 [entrez]
AID - S0967-5868(06)00113-5 [pii]
AID - 10.1016/j.jocn.2005.04.028 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2006 Apr;13(3):353-5. doi: 10.1016/j.jocn.2005.04.028. Epub 2006 
      Mar 20.