PMID- 16547209
OWN - NLM
STAT- MEDLINE
DCOM- 20060814
LR  - 20220309
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Print)
IS  - 1355-6037 (Linking)
VI  - 92
IP  - 8
DP  - 2006 Aug
TI  - Relation between proinflammatory to anti-inflammatory cytokine ratios and 
      long-term prognosis in patients with non-ST elevation acute coronary syndrome.
PG  - 1041-6
AB  - OBJECTIVE: To investigate the relation between serum high sensitivity (hs) C 
      reactive protein (CRP), proinflammatory cytokine concentrations, proinflammatory 
      to anti-inflammatory cytokine ratios and long-term prognosis in patients with 
      non-ST elevation acute coronary syndrome (NSTEACS). DESIGN: Prospective follow-up 
      study for the first six months and then for the first year after admission to 
      hospital. SETTING: Tertiary referral centre. PATIENTS: 80 patients (60 men, 20 
      women, mean age 60 (SD 10) years) with NSTEACS and moderate to high TIMI 
      (Thrombolysis In Myocardial Infarction) risk scores. INTERVENTIONS: Blood samples 
      from patients with NSTEACS were obtained at the time of admission. Serum 
      concentrations of hs-CRP, (hs) pro-inflammatory (interleukin (IL) -1beta, IL-6, 
      tumour necrosis factor alpha) and (hs) anti-inflammatory (IL-10) cytokines were 
      analysed and proinflammatory to anti-inflammatory cytokine ratios were calculated 
      by dividing proinflammatory cytokine concentrations by anti-inflammatory cytokine 
      IL-10. MAIN OUTCOME MEASURE: The primary end point of the study was new coronary 
      events (NCE) defined as the combination of cardiac death, non-fatal myocardial 
      infarction and recurrent rest angina that required hospitalisation within 12 
      months of follow up. RESULTS: During the one-year follow-up period, 23 patients 
      (29%) met the NCE criteria. Concentrations of hs-CRP, IL-1beta and IL-6 and 
      ratios of IL-1beta:IL-10 and IL-6:IL-10 were significantly higher in patients 
      with NCE than in patients without NCE. In the logistic regression analysis, 
      IL-6:IL-10 ratio was the most important predictor for NCE (p = 0.006) with an 
      odds ratio of 2.24 (95% CI 1.26 to 3.97). CONCLUSIONS: Cytokine concentrations 
      and proinflammatory to anti-inflammatory cytokine ratios may be useful markers 
      for predicting vascular risk in patients with NSTEACS.
FAU - Kilic, T
AU  - Kilic T
AD  - Department of Cardiology, University of Kocaeli, Kocaeli, Turkey. 
      kilicteoman@yahoo.com
FAU - Ural, D
AU  - Ural D
FAU - Ural, E
AU  - Ural E
FAU - Yumuk, Z
AU  - Yumuk Z
FAU - Agacdiken, A
AU  - Agacdiken A
FAU - Sahin, T
AU  - Sahin T
FAU - Kahraman, G
AU  - Kahraman G
FAU - Kozdag, G
AU  - Kozdag G
FAU - Vural, A
AU  - Vural A
FAU - Komsuoglu, B
AU  - Komsuoglu B
LA  - eng
PT  - Journal Article
DEP - 20060317
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
RN  - 0 (Cytokines)
SB  - IM
MH  - Angina Pectoris/blood
MH  - Coronary Angiography
MH  - Coronary Disease/*blood/surgery
MH  - Cytokines/*metabolism
MH  - Death, Sudden, Cardiac/etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood
MH  - Myocardial Revascularization
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Recurrence
MH  - Risk Factors
PMC - PMC1861097
EDAT- 2006/03/21 09:00
MHDA- 2006/08/15 09:00
PMCR- 2009/08/01
CRDT- 2006/03/21 09:00
PHST- 2006/03/21 09:00 [pubmed]
PHST- 2006/08/15 09:00 [medline]
PHST- 2006/03/21 09:00 [entrez]
PHST- 2009/08/01 00:00 [pmc-release]
AID - hrt.2005.080382 [pii]
AID - ht80382 [pii]
AID - 10.1136/hrt.2005.080382 [doi]
PST - ppublish
SO  - Heart. 2006 Aug;92(8):1041-6. doi: 10.1136/hrt.2005.080382. Epub 2006 Mar 17.