PMID- 16547466
OWN - NLM
STAT- MEDLINE
DCOM- 20060808
LR  - 20230210
IS  - 0893-3952 (Print)
IS  - 0893-3952 (Linking)
VI  - 19
IP  - 6
DP  - 2006 Jun
TI  - Analysis of ovarian teratomas for isochromosome 12p: evidence supporting a dual 
      histogenetic pathway for teratomatous elements.
PG  - 766-71
AB  - Teratomas are the most common germ cell tumor (GCT) of the ovary and include 
      several types with a range of clinical behavior. As in testicular teratomas, they 
      may be benign, malignant or a component of a mixed GCT. In the testis, data 
      support separate pathogeneses for prepubertal and postpubertal teratomas, with 
      derivation of the former from a nontransformed germ cell and the latter from 
      differentiation of a nonteratomatous, malignant GCT. The absence of cytogenetic 
      abnormalities (including isochromosome 12p (i(12p)) in mature ovarian teratomas 
      suggests that they may be analogous to prepubertal testicular teratomas, but 
      there are no data regarding genetic changes in the teratomatous components of 
      ovarian mixed GCTs. We therefore studied the teratomatous components of six mixed 
      GCTs of the ovary using fluorescence in situ hybridization (FISH) for i(12p). Six 
      mixed GCTs of the ovary occurred in patients 4-33 years of age; all had 
      teratomatous and yolk sac tumor components and three also contained foci of 
      embryonal carcinoma. Using FISH with 12p telomeric and 12 centromeric probes, 
      five of six (83%) cases had detectable i(12p) in their nonteratomatous 
      components, and four of six (66%) in the teratomatous component. One of the two 
      cases without demonstrable i(12p) in the teratomatous portion of the mixed GCT 
      also did not have identifiable 12p abnormalities in other elements of the mixed 
      GCT. By comparison, five pure, mature ovarian teratomas and three pure, immature 
      ovarian teratomas showed no evidence of either i(12p) or other forms of 12p 
      amplification. These findings support that teratoma in mixed ovarian GCTs has a 
      different pathogenesis compared to pure teratoma of the ovary. Furthermore, the 
      findings of i(12p) in both the teratomatous and nonteratomatous components of 
      ovarian mixed GCTs supports that the teratoma derives from other components, 
      similar to the situation in the testis.
FAU - Poulos, Christopher
AU  - Poulos C
AD  - Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 
      46202-5280, USA.
FAU - Cheng, Liang
AU  - Cheng L
FAU - Zhang, Shaobo
AU  - Zhang S
FAU - Gersell, Deborah J
AU  - Gersell DJ
FAU - Ulbright, Thomas M
AU  - Ulbright TM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - *Chromosomes, Human, Pair 12
MH  - Female
MH  - *Gene Amplification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Isochromosomes/*genetics
MH  - Ovarian Neoplasms/*genetics/pathology
MH  - Teratoma/*genetics/pathology
EDAT- 2006/03/21 09:00
MHDA- 2006/08/09 09:00
CRDT- 2006/03/21 09:00
PHST- 2006/03/21 09:00 [pubmed]
PHST- 2006/08/09 09:00 [medline]
PHST- 2006/03/21 09:00 [entrez]
AID - S0893-3952(22)02008-7 [pii]
AID - 10.1038/modpathol.3800596 [doi]
PST - ppublish
SO  - Mod Pathol. 2006 Jun;19(6):766-71. doi: 10.1038/modpathol.3800596.