PMID- 16548356
OWN - NLM
STAT- MEDLINE
DCOM- 20071227
LR  - 20221207
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 26
IP  - 2
DP  - 2006 Feb
TI  - [Experimental study on effect of matrine in alleviating renal tubulointerstitial 
      fibrosis in unilateral ureteral obstruction model].
PG  - 140-3
AB  - OBJECTIVE: To observe the effects of matrine on renal tubulointerstitial fibrosis 
      in unilateral ureteral obstruction (UUO) rat model and to explore its mechanisms. 
      METHODS: Model rats of UUO were established and randomly divided into 6 groups: 
      the normal group, the sham group, the UUO model group, the fusinopril treated 
      group (F group), the high dose and low dose matrine treated groups (HM and LM). 
      The expressions of matrix metalloproteinase-3 ( MMP-3), tissue inhibitor of 
      metalloproteinase-1 (TIMP-1), fibronectin (FN), connective tissue growth factor 
      (CTGF) and alpha-smooth muscle actin (alpha-SMA) were determined 
      semi-quantitatively by immunohistochemistry on the 14th day. RESULTS: The 
      expression of MMP-3 in the UUO model rats was significantly lowed on the 14th 
      day, compared with that in rats not modeled in the normal and the sham groups (P 
      < 0.05), but it was higher in the three treated groups than that in the UUO model 
      group (P < 0.05); the expressions of TIMP-1, FN, CTGF and alpha-SMA were lower in 
      the normal group and sham UUO group than those in all the UUO model groups, while 
      they were lower obviously in the three treated groups than those in the UUO model 
      group (P < 0.05); there was no significant difference in the above-mentioned 
      indexes between HM group and F group (P < 0.05). CONCLUSION: Matrine could 
      decrease the expressions of TIMP-1, FN, CTGF and alpha-SMA in the 
      tubulointerstitium, and partly restore the expression of MMP-3, so as to delay 
      the progression of renal tubulointerstitial fibrosis.
FAU - Fu, Ping
AU  - Fu P
AD  - Department of Nephrology, Huaxi Hospital, Sichuan University, Chengdu 450000. 
      fuping9@hotmail.com
FAU - Feng, Mei
AU  - Feng M
FAU - Zhang, Zhu
AU  - Zhang Z
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Alkaloids)
RN  - 0 (Fibronectins)
RN  - 0 (Quinolizines)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - 0 (Matrines)
SB  - IM
MH  - Alkaloids/pharmacology/*therapeutic use
MH  - Animals
MH  - Fibronectins/biosynthesis/genetics
MH  - Fibrosis/drug therapy/etiology
MH  - Kidney Tubules/*pathology
MH  - Male
MH  - Matrix Metalloproteinase 3/biosynthesis/genetics
MH  - *Phytotherapy
MH  - Quinolizines/pharmacology/*therapeutic use
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tissue Inhibitor of Metalloproteinase-1/biosynthesis/genetics
MH  - Ureteral Obstruction/*complications
MH  - Matrines
EDAT- 2006/03/22 09:00
MHDA- 2007/12/28 09:00
CRDT- 2006/03/22 09:00
PHST- 2006/03/22 09:00 [pubmed]
PHST- 2007/12/28 09:00 [medline]
PHST- 2006/03/22 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Feb;26(2):140-3.