PMID- 16548761
OWN - NLM
STAT- MEDLINE
DCOM- 20060612
LR  - 20191026
IS  - 1744-7682 (Electronic)
IS  - 1471-2598 (Linking)
VI  - 6
IP  - 4
DP  - 2006 Apr
TI  - Dendritic cells as promoters of transplant tolerance.
PG  - 325-39
AB  - Dendritic cells (DCs) play a crucial role during the initiation of immune 
      responses against non-self antigens. Following organ transplantation, activated 
      donor- and recipient-derived DCs participate actively in graft rejection by 
      sensitising recipient T cells via the direct or indirect pathways of 
      allorecognition, respectively. There is increasing evidence that 
      immature/semi-mature DCs induce antigen-specific unresponsiveness or tolerance to 
      self antigens, both in central lymphoid tissue and in the periphery, through a 
      variety of mechanisms (deletion, anergy and regulation). In the past few years, 
      DC-based therapy of experimental allograft rejection has focused on ex vivo 
      biological, pharmacological and genetic engineering of DCs to mimic/enhance their 
      natural tolerogenicity. Successful outcomes in rodent models have built the case 
      that DC-based therapy may provide a novel approach to transplant tolerance. 
      Ongoing research into the role that DCs play in the induction of tolerance should 
      allow for its clinical application in the near future.
FAU - Nouri-Shirazi, Mahyar
AU  - Nouri-Shirazi M
AD  - Texas A&M University System Health Science Center, Baylor College of Dentistry, 
      Department of Biomedical Sciences, Immunology Laboratory, 3302 Gaston Avenue, 
      Dallas, TX 75246, USA. MNShirazi@bcd.tamhsc.edu
FAU - Thomson, Angus W
AU  - Thomson AW
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Transplantation Tolerance/*immunology
RF  - 150
EDAT- 2006/03/22 09:00
MHDA- 2006/06/13 09:00
CRDT- 2006/03/22 09:00
PHST- 2006/03/22 09:00 [pubmed]
PHST- 2006/06/13 09:00 [medline]
PHST- 2006/03/22 09:00 [entrez]
AID - 10.1517/14712598.6.4.325 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2006 Apr;6(4):325-39. doi: 10.1517/14712598.6.4.325.