PMID- 16548900
OWN - NLM
STAT- MEDLINE
DCOM- 20060727
LR  - 20151119
IS  - 1323-7799 (Print)
IS  - 1323-7799 (Linking)
VI  - 11
IP  - 2
DP  - 2006 Mar
TI  - Increased plasma monocyte chemoattractant protein-1 level in idiopathic pulmonary 
      arterial hypertension.
PG  - 158-63
AB  - OBJECTIVE: Monocyte chemoattractant protein-1 (MCP-1), a pro-inflammatory 
      chemokine, has potent chemoattractant activity for monocytes/macrophages. We 
      sought to investigate the clinical significance of MCP-1 in idiopathic pulmonary 
      arterial hypertension (IPAH). METHODS: This study included 28 patients with IPAH, 
      seven patients with pulmonary arterial hypertension (PAH) related to collagen 
      vascular disease, and 13 healthy subjects. Plasma MCP-1 levels were measured 
      together with serum IL-6 and tumour necrosis factor-alpha (TNF-alpha) levels. 
      RESULTS: Circulating levels of MCP-1, IL-6 and TNF-alpha were significantly 
      higher in patients with IPAH than in healthy controls, although they were lower 
      than in patients with PAH related to collagen vascular disease. Plasma MCP-1 did 
      not significantly correlate with any haemodynamic variables. However, plasma 
      MCP-1 levels correlated negatively with the disease duration (time from symptom 
      onset). CONCLUSIONS: Plasma MCP-1 levels were elevated in patients with IPAH, and 
      this elevation was particularly marked in the early stage of disease. Taking into 
      account the chemoattractant activity of MCP-1, these results imply a contribution 
      of MCP-1 to the development of pulmonary hypertension.
FAU - Itoh, Takefumi
AU  - Itoh T
AD  - Department of Regenerative Medicine and Tissue Engineering, National 
      Cardiovascular Center Research Institute, Osaka, Japan.
FAU - Nagaya, Noritoshi
AU  - Nagaya N
FAU - Ishibashi-Ueda, Hatsue
AU  - Ishibashi-Ueda H
FAU - Kyotani, Shingo
AU  - Kyotani S
FAU - Oya, Hideo
AU  - Oya H
FAU - Sakamaki, Fumio
AU  - Sakamaki F
FAU - Kimura, Hiroshi
AU  - Kimura H
FAU - Nakanishi, Norifumi
AU  - Nakanishi N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/*blood/physiopathology
MH  - Immunoenzyme Techniques
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Wedge Pressure/physiology
MH  - Severity of Illness Index
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2006/03/22 09:00
MHDA- 2006/07/28 09:00
CRDT- 2006/03/22 09:00
PHST- 2006/03/22 09:00 [pubmed]
PHST- 2006/07/28 09:00 [medline]
PHST- 2006/03/22 09:00 [entrez]
AID - RES [pii]
AID - 10.1111/j.1440-1843.2006.00821.x [doi]
PST - ppublish
SO  - Respirology. 2006 Mar;11(2):158-63. doi: 10.1111/j.1440-1843.2006.00821.x.