PMID- 16552047
OWN - NLM
STAT- MEDLINE
DCOM- 20060510
LR  - 20181113
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 74
IP  - 4
DP  - 2006 Apr
TI  - Correlation between eosinophils and protection against reinfection with 
      Schistosoma mansoni and the effect of human immunodeficiency virus type 1 
      coinfection in humans.
PG  - 2169-76
AB  - Longitudinal investigations of an adult male population of Kenyan car washers who 
      have heavy and quantifiable occupational exposure to Schistosoma mansoni 
      cercariae revealed that some individuals develop resistance to reinfection while 
      others remain highly susceptible. We sought to characterize immune correlates 
      associated with host protection in this population. Previous studies have 
      demonstrated an association of peripheral eosinophilia with resistance to 
      reinfection with schistosomes. Thus, we investigated the relationship between the 
      percentage of circulating eosinophils and the effect of human immunodeficiency 
      virus type 1 (HIV-1) coinfection on the susceptibility of the car washers to 
      reinfection with schistosomes. Elevated percentages of circulating eosinophils 
      were associated with resistance to reinfection by S. mansoni in 
      HIV-1-seronegative persons. In the HIV-1-seropositive cohort, low CD4+-T-cell 
      counts were associated with a less intense eosinophilia. Moreover, eosinophils 
      from the car washers expressed high levels of FcepsilonRI beta chain, a molecule 
      important in immunoglobulin E (IgE)-mediated immunity. Levels of FcepsilonRI beta 
      chain expression correlated with serum levels of total and antigen-specific IgE 
      for HIV-1-negative car washers, but this was not the case for individuals 
      coinfected with HIV-1. Overall, these data further implicate eosinophils as 
      having a potential role in development of protective immunity against 
      schistosomes and suggest that changes associated with HIV-1 coinfection increase 
      susceptibility to reinfection.
FAU - Ganley-Leal, Lisa M
AU  - Ganley-Leal LM
AD  - Centers for Disease Control and Prevention, Division of Parasitic Diseases, 4770 
      Buford Hwy, N.E., Atlanta, GA 30341, USA.
FAU - Mwinzi, Pauline N
AU  - Mwinzi PN
FAU - Cetre-Sossah, Catherine B
AU  - Cetre-Sossah CB
FAU - Andove, Julius
AU  - Andove J
FAU - Hightower, Allen W
AU  - Hightower AW
FAU - Karanja, Diana M S
AU  - Karanja DM
FAU - Colley, Daniel G
AU  - Colley DG
FAU - Secor, W Evan
AU  - Secor WE
LA  - eng
GR  - R01 AI053695/AI/NIAID NIH HHS/United States
GR  - T32 AI052070/AI/NIAID NIH HHS/United States
GR  - AI053695/AI/NIAID NIH HHS/United States
GR  - T32 AI52070/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Interleukin-5)
RN  - 0 (MS4A2 protein, human)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Cells, Cultured
MH  - Eosinophilia/immunology
MH  - Eosinophils/*immunology/metabolism
MH  - HIV Infections/*immunology/parasitology
MH  - HIV-1/*immunology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interleukin-5/biosynthesis
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Receptors, IgE/biosynthesis/blood/genetics
MH  - Schistosoma mansoni/*immunology
MH  - Schistosomiasis mansoni/*immunology/*prevention & control/virology
MH  - Secondary Prevention
PMC - PMC1418888
EDAT- 2006/03/23 09:00
MHDA- 2006/05/11 09:00
PMCR- 2006/04/01
CRDT- 2006/03/23 09:00
PHST- 2006/03/23 09:00 [pubmed]
PHST- 2006/05/11 09:00 [medline]
PHST- 2006/03/23 09:00 [entrez]
PHST- 2006/04/01 00:00 [pmc-release]
AID - 74/4/2169 [pii]
AID - 1744-05 [pii]
AID - 10.1128/IAI.74.4.2169-2176.2006 [doi]
PST - ppublish
SO  - Infect Immun. 2006 Apr;74(4):2169-76. doi: 10.1128/IAI.74.4.2169-2176.2006.