PMID- 16553536
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20221207
IS  - 1044-5463 (Print)
IS  - 1044-5463 (Linking)
VI  - 16
IP  - 1-2
DP  - 2006 Feb-Apr
TI  - Treatment-emergent adverse events from selective serotonin reuptake inhibitors by 
      age group: children versus adolescents.
PG  - 159-69
AB  - OBJECTIVE: The aim of this study was to report the frequency of common 
      treatment-emergent adverse events (AEs) from selective serotonin reuptake 
      inhibitors (SSRIs) in children, adolescents, and adults. METHOD: AE data were 
      obtained from all published double-blind, placebo-controlled SSRI studies of 
      children and adolescents that separated AE findings by age group. The AE findings 
      were pooled for purposes of age-group comparisons. Double-blind, 
      placebo-controlled SSRI studies of adolescents (n = 2) and of adults identified 
      in systematically identified trials (n = 22) were assessed to compare patterns 
      and rates across the age span. Other reports, primarily from the published SSRI 
      literature, were added to clarify the findings presented. RESULTS: Activation and 
      vomiting SSRI AEs were 2- to 3-fold more prevalent in children than in 
      adolescents, and their rate was lowest in adults. Somnolence as a SSRI AE was 
      uncommon in children; its rate increased with advancing age. Insomnia and nausea 
      were common SSRI AEs across the age span. Activation AEs were a frequent reason 
      for discontinuation from SSRI clinical trials in preadolescents, whereas 
      somnolence, nausea, and insomnia AEs were the most common reasons for trial 
      discontinuations in adults. CONCLUSIONS: Children are particularly vulnerable to 
      specific AEs from certain medications, such as SSRIs. It is likely that the level 
      of children's biological immaturity explains part of this phenomenon.
FAU - Safer, Daniel J
AU  - Safer DJ
AD  - Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA. 
      dsafer@jhmi.edu
FAU - Zito, Julie Magno
AU  - Zito JM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Child Adolesc Psychopharmacol
JT  - Journal of child and adolescent psychopharmacology
JID - 9105358
RN  - 0 (Serotonin Uptake Inhibitors)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Child
MH  - *Controlled Clinical Trials as Topic/psychology
MH  - Humans
MH  - Selective Serotonin Reuptake Inhibitors/*adverse effects
MH  - Treatment Outcome
RF  - 60
EDAT- 2006/03/24 09:00
MHDA- 2006/08/19 09:00
CRDT- 2006/03/24 09:00
PHST- 2006/03/24 09:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2006/03/24 09:00 [entrez]
AID - 10.1089/cap.2006.16.159 [doi]
PST - ppublish
SO  - J Child Adolesc Psychopharmacol. 2006 Feb-Apr;16(1-2):159-69. doi: 
      10.1089/cap.2006.16.159.