PMID- 16554479
OWN - NLM
STAT- MEDLINE
DCOM- 20060414
LR  - 20200225
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 26
IP  - 12
DP  - 2006 Mar 22
TI  - Adrenergic enhancement of inhibitory transmission in the accessory olfactory 
      bulb.
PG  - 3292-8
AB  - Noradrenergic modulation of dendrodendritic synapses between the mitral and 
      granule cells in the accessory olfactory bulb (AOB) is postulated to play a key 
      role in the formation of memory in olfactory-mediated behaviors. Current models 
      propose that noradrenaline (NA) increases excitation of mitral/tufted cells 
      (M/TCs) by decreasing the release of GABA from granule cells. However, 
      surprisingly little is known about the actions of NA at the cellular level in the 
      AOB. Here, in recordings from AOB slices, we show that NA decreases the firing 
      frequency of M/TCs in response to stimulation. This effect is attributable to an 
      increase in the GABA inhibitory input to M/TCs. Application of NA (10 microM) 
      produced an approximately 20-fold increase in the frequency of GABA-induced 
      miniature IPSCs (mIPSCs) without changing their amplitude. A pharmacological 
      analysis indicated that the increase in mIPSCs frequency results from activation 
      of alpha1 adrenergic receptors. In addition to increasing the mIPSC frequency, NA 
      also potentiated GABA inhibitory currents induced by direct stimulation of 
      granule cells. Together, our results suggest that NA increases the release of 
      GABA from granule cells by acting on presynaptic receptors. Thus, the role of the 
      noradrenergic activity in the AOB may be opposite than suggested previously: we 
      find that the overall effect of NA in the AOB is inhibition of M/TCs.
FAU - Araneda, Ricardo C
AU  - Araneda RC
AD  - Department of Biological Sciences, Columbia University, New York, New York 10027, 
      USA. rca23@columbia.edu
FAU - Firestein, Stuart
AU  - Firestein S
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Adra1a protein, mouse)
RN  - 0 (Receptors, Adrenergic, alpha-1)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Action Potentials/drug effects/physiology
MH  - Animals
MH  - Dendrites/drug effects/metabolism
MH  - Female
MH  - Male
MH  - Memory/drug effects/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neural Inhibition/drug effects/*physiology
MH  - Neurons/drug effects/*metabolism
MH  - Norepinephrine/*metabolism/pharmacology
MH  - Olfactory Bulb/drug effects/*physiology
MH  - Organ Culture Techniques
MH  - Presynaptic Terminals/drug effects/metabolism
MH  - Receptors, Adrenergic, alpha-1/drug effects/metabolism
MH  - Smell/drug effects/physiology
MH  - Synapses/drug effects/*metabolism
MH  - Synaptic Transmission/drug effects/*physiology
MH  - gamma-Aminobutyric Acid/metabolism
PMC - PMC6674102
EDAT- 2006/03/24 09:00
MHDA- 2006/04/15 09:00
PMCR- 2006/09/22
CRDT- 2006/03/24 09:00
PHST- 2006/03/24 09:00 [pubmed]
PHST- 2006/04/15 09:00 [medline]
PHST- 2006/03/24 09:00 [entrez]
PHST- 2006/09/22 00:00 [pmc-release]
AID - 26/12/3292 [pii]
AID - 10.1523/JNEUROSCI.4768-05.2006 [doi]
PST - ppublish
SO  - J Neurosci. 2006 Mar 22;26(12):3292-8. doi: 10.1523/JNEUROSCI.4768-05.2006.