PMID- 16554730
OWN - NLM
STAT- MEDLINE
DCOM- 20060710
LR  - 20230210
IS  - 0893-3952 (Print)
IS  - 0893-3952 (Linking)
VI  - 19
IP  - 4
DP  - 2006 Apr
TI  - Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 
      17 and losses of chromosome Y that are prevalent in papillary renal cell 
      carcinoma.
PG  - 488-93
AB  - Mucinous tubular and spindle cell carcinoma of the kidney is an uncommon, 
      distinctive neoplasm characterized by the proliferation of cuboidal and spindle 
      cells arranged in tubular or sheet-like arrays, typically with a mucinous or 
      myxoid background. The most important differential diagnostic consideration of 
      mucinous tubular and spindle cell carcinoma is papillary renal cell carcinoma, 
      type 1, with sarcomatoid transformation. The aim of our study is to investigate 
      the pattern of possible gains or losses of chromosomes 7, 17 and Y in 10 mucinous 
      tubular and spindle cell carcinomas with interphase fluorescence in situ 
      hybridization (FISH). Four-micron sections were obtained from paraffin blocks 
      representative of the tumors and including adjacent non-neoplastic renal 
      parenchyma from 10 patients. The patients' ages ranged from 20 to 80 years (mean: 
      62 years); eight were female, while two were male. FISH analysis was performed 
      with centromeric probes for chromosomes 7, 17 and Y. One hundred fifty to 200 
      nuclei from each case were scored for hybridization signals and non-neoplastic 
      parenchyma served as control tissue. We found that renal mucinous tubular and 
      spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of 
      chromosome Y that are typical of papillary renal cell carcinoma. FISH analysis 
      with centromeric probes for these chromosomes is potentially helpful in 
      differentiating mucinous tubular and spindle cell carcinomas from papillary renal 
      cell carcinomas.
FAU - Cossu-Rocca, Paolo
AU  - Cossu-Rocca P
AD  - Department of Pathology, Indiana University Medical Center, University Hospital, 
      Indianapolis, IN 46202, USA.
FAU - Eble, John N
AU  - Eble JN
FAU - Delahunt, Brett
AU  - Delahunt B
FAU - Zhang, Shaobo
AU  - Zhang S
FAU - Martignoni, Guido
AU  - Martignoni G
FAU - Brunelli, Matteo
AU  - Brunelli M
FAU - Cheng, Liang
AU  - Cheng L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
SB  - IM
MH  - Adenocarcinoma, Mucinous/genetics/*pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Papillary/genetics/*pathology
MH  - Carcinoma, Renal Cell/genetics/*pathology
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Chromosomes, Human, Pair 7/genetics
MH  - Chromosomes, Human, Y/genetics
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/genetics/*pathology
MH  - Male
MH  - Middle Aged
EDAT- 2006/03/24 09:00
MHDA- 2006/07/13 09:00
CRDT- 2006/03/24 09:00
PHST- 2006/03/24 09:00 [pubmed]
PHST- 2006/07/13 09:00 [medline]
PHST- 2006/03/24 09:00 [entrez]
AID - S0893-3952(22)03377-4 [pii]
AID - 10.1038/modpathol.3800565 [doi]
PST - ppublish
SO  - Mod Pathol. 2006 Apr;19(4):488-93. doi: 10.1038/modpathol.3800565.