PMID- 16554737
OWN - NLM
STAT- MEDLINE
DCOM- 20060710
LR  - 20230210
IS  - 0893-3952 (Print)
IS  - 0893-3952 (Linking)
VI  - 19
IP  - 4
DP  - 2006 Apr
TI  - Chromosome 12p abnormalities in dysgerminoma of the ovary: a FISH analysis.
PG  - 611-5
AB  - Dysgerminoma is the most common malignant ovarian germ cell tumor and shares 
      histological and immunophenotypical features with its testicular counterpart, 
      seminoma. Chromosome 12p abnormalities are genetic hallmarks of testicular 
      seminomas. Little is known about these genetic changes in dysgerminoma. We 
      performed dual color fluorescence in situ hybridization (FISH) analyses with a 
      centromeric alpha-satellite probe for chromosome 12 and a subtelomeric probe for 
      12p on paraffin-embedded tissue sections from 21 dysgerminomas and two 
      gonadoblastomas. Chromosome 12p abnormalities were detected in 81% of 
      dysgerminomas. In all, 57% of cases had only isochromosome 12p and 5% had only 
      12p overrepresentation. In all, 19% had both isochrome 12p and 12p 
      overrepresentation. Gonadoblastomas were negative for isochromosome 12p or 12p 
      overrepresentation. Chromosome 12p abnormalities are common in dysgerminoma of 
      the ovary. FISH analyses for chromosome 12p abnormalities may be a useful 
      diagnostic adjunct for confirming the diagnosis of dysgerminoma and for 
      distinguishing it from nongerm cell malignancies that enter into the differential 
      diagnosis.
FAU - Cossu-Rocca, Paolo
AU  - Cossu-Rocca P
AD  - Department of Pathology, Indiana University, Indianapolis, IN 46202, USA.
FAU - Zhang, Shaobo
AU  - Zhang S
FAU - Roth, Lawrence M
AU  - Roth LM
FAU - Eble, John N
AU  - Eble JN
FAU - Zheng, Wenxin
AU  - Zheng W
FAU - Karim, Fadi W Abdul
AU  - Karim FW
FAU - Michael, Helen
AU  - Michael H
FAU - Emerson, Robert E
AU  - Emerson RE
FAU - Jones, Timothy D
AU  - Jones TD
FAU - Hattab, Eyas M
AU  - Hattab EM
FAU - Cheng, Liang
AU  - Cheng L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - Dysgerminoma/genetics/*pathology
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Middle Aged
MH  - Ovarian Neoplasms/genetics/*pathology
EDAT- 2006/03/24 09:00
MHDA- 2006/07/13 09:00
CRDT- 2006/03/24 09:00
PHST- 2006/03/24 09:00 [pubmed]
PHST- 2006/07/13 09:00 [medline]
PHST- 2006/03/24 09:00 [entrez]
AID - S0893-3952(22)03392-0 [pii]
AID - 10.1038/modpathol.3800576 [doi]
PST - ppublish
SO  - Mod Pathol. 2006 Apr;19(4):611-5. doi: 10.1038/modpathol.3800576.