PMID- 16555323
OWN - NLM
STAT- MEDLINE
DCOM- 20060912
LR  - 20221207
IS  - 1527-6465 (Print)
IS  - 1527-6465 (Linking)
VI  - 12
IP  - 4
DP  - 2006 Apr
TI  - The association of HLA-DR13 with lower graft survival rates in hepatitis B and 
      primary sclerosing cholangitis Caucasian patients receiving a liver transplant.
PG  - 600-4
AB  - We investigated an association of human leukocyte antigen (HLA)-DR13 to graft 
      survival in liver transplantation among Caucasian recipients. 28,708 deceased 
      liver transplants performed between January 1990 and December 2002 in the United 
      States as reported to the United Network for Organ Sharing registry were utilized 
      to compare survival rates. We utilized Caucasian adult patients (>20 years) by 
      Kaplan-Meier curves, log-rank tests, and Cox proportional hazard analyses. 
      HLA-DR13-negative hepatitis B virus (HBV) and primary sclerosing cholangitis 
      (PSC) recipients yielded significantly lower graft survival rates than those of 
      DR13-negative patients (P = 0.002, P = 0.015, respectively). This negative 
      association was still significant after adjusting potential confounding factors. 
      The Cox test demonstrated that HLA-DR13-positive groups have a significantly 
      higher hazard ratio in PSC (1.40; P = 0.029; 95% confidence interval, 1.04-1.90) 
      and HBV patients (1.78; P = 0.032; 95% confidence interval, 1.05-3.02). In 
      conclusion, our data suggest that HLA-DR13 is a strong, positive predictor of 
      increased risk for graft loss in HBV and PSC liver transplant recipients. Further 
      study is needed to test the hypothesis that DR13-related immune responses may 
      play a role in mediating graft loss in HBV and PSC liver transplantations.
CI  - Copyright 2006 AASLD
FAU - Futagawa, Yasuro
AU  - Futagawa Y
AD  - Terasaki Foundation Laboratory, Los Angeles, CA 90064, USA. 
      yasuro@terasakilab.org
FAU - Waki, Kayo
AU  - Waki K
FAU - Cai, Junchao
AU  - Cai J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR13 antigen)
SB  - IM
MH  - Biomarkers/blood
MH  - Cholangitis, Sclerosing/*surgery
MH  - Graft Survival
MH  - HLA-DR Antigens/*blood
MH  - HLA-DR Serological Subtypes
MH  - Hepatitis B/*surgery
MH  - Humans
MH  - Liver Transplantation/mortality/*physiology
MH  - *Living Donors
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Time Factors
MH  - White People
EDAT- 2006/03/24 09:00
MHDA- 2006/09/13 09:00
CRDT- 2006/03/24 09:00
PHST- 2006/03/24 09:00 [pubmed]
PHST- 2006/09/13 09:00 [medline]
PHST- 2006/03/24 09:00 [entrez]
AID - 10.1002/lt.20678 [doi]
PST - ppublish
SO  - Liver Transpl. 2006 Apr;12(4):600-4. doi: 10.1002/lt.20678.