PMID- 1655594
OWN - NLM
STAT- MEDLINE
DCOM- 19911029
LR  - 20220408
IS  - 0090-8258 (Print)
IS  - 0090-8258 (Linking)
VI  - 42
IP  - 1
DP  - 1991 Jul
TI  - Small cell carcinoma of the cervix: a clinical and flow-cytometric study.
PG  - 27-33
AB  - The clinical course of 14 patients diagnosed with small cell carcinoma of the 
      cervix (SCC) was reviewed and compared to that of 37 cases of undifferentiated 
      large cell nonkeratonizing carcinoma (LCNK). We observed the following 
      differences between the two: SCC patients had a higher incidence of pelvic wall 
      involvement and distant metastasis; the development of progressive disease was 
      more frequent in SCC than in LCNK patients; median survival time was 9 months in 
      SCC and 40 months in LCNK patients; flow cytometry revealed aneuploidy in all SCC 
      and in 30% of the LCNK patients; the mean DNA index was 2.24 in SCC, 
      significantly higher than in LCNK (1.15). DNA index in cases of SCC was related 
      to survival time. SCC of the cervix is an extremely aggressive tumor, even when 
      compared to other undifferentiated cervical cancers. Aneuploidy is a consistent 
      feature and thus helpful for diagnosis. Due to the wide range of values, the DNA 
      index cannot be used for diagnostic purposes, but it is of prognostic importance 
      in SCC cases.
FAU - Miller, B
AU  - Miller B
AD  - Department of Gynecology and Pathology, University of Tennessee, College of 
      Medicine, Memphis.
FAU - Dockter, M
AU  - Dockter M
FAU - el Torky, M
AU  - el Torky M
FAU - Photopulos, G
AU  - Photopulos G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Gynecol Oncol
JT  - Gynecologic oncology
JID - 0365304
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aneuploidy
MH  - Carcinoma/genetics/pathology
MH  - Carcinoma, Small Cell/genetics/*pathology
MH  - DNA, Neoplasm/metabolism
MH  - Female
MH  - *Flow Cytometry
MH  - Follow-Up Studies
MH  - Humans
MH  - Middle Aged
MH  - Prognosis
MH  - Uterine Cervical Neoplasms/genetics/*pathology
EDAT- 1991/07/01 00:00
MHDA- 1991/07/01 00:01
CRDT- 1991/07/01 00:00
PHST- 1991/07/01 00:00 [pubmed]
PHST- 1991/07/01 00:01 [medline]
PHST- 1991/07/01 00:00 [entrez]
AID - 10.1016/0090-8258(91)90225-t [doi]
PST - ppublish
SO  - Gynecol Oncol. 1991 Jul;42(1):27-33. doi: 10.1016/0090-8258(91)90225-t.