PMID- 16556437
OWN - NLM
STAT- MEDLINE
DCOM- 20060706
LR  - 20220311
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1081
IP  - 1
DP  - 2006 Apr 7
TI  - Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory.
PG  - 72-8
AB  - Nicotinic receptor systems have been shown to be important for working memory. In 
      general, nicotinic agonists have been shown to improve memory, and nicotinic 
      antagonists impair it. All of the neuronal substrates for nicotinic involvement 
      in memory still remain to be discovered. The amygdala and ventral hippocampus 
      have both been found to be important for nicotinic involvement in memory 
      function. Local infusion of the nicotinic antagonist methyllycaconitine (MLA) to 
      block alpha7 nicotinic receptors and dihydro-beta-erythrodine (DHbetaE) to block 
      alpha4beta2 nicotinic receptors into the basolateral amygdala and the ventral 
      hippocampus have been found to impair working memory function, with no additive 
      effects being observed. The current project assessed the roles of alpha7 and 
      alpha4beta2 nicotinic receptors in the dorsal hippocampus for memory function. 
      Adult female Sprague-Dawley rats were trained on the 16-arm radial maze. The rats 
      (n = 10) had bilateral cannulae implanted into the dorsal hippocampus. The rats 
      were given acute infusions of DHbetaE (0, 1.69, 3.38, and 6.75 microg/side) and 
      MLA (6.75 microg/side) alone and in combination in a repeated measures 
      counter-balanced design. DHbetaE and MLA infusion into the dorsal hippocampus 
      significantly increased working memory errors. However, when the two drugs were 
      given in combination, an attenuated effect was seen. No significant effects of 
      MLA or DHbetaE were seen with reference memory errors or response latency. These 
      results confirm the importance of alpha4beta2 and alpha7 nicotinic acetylcholine 
      receptors in the dorsal hippocampus for appetitively-motivated spatial cognitive 
      function.
FAU - Nott, Alexi
AU  - Nott A
AD  - Department of Psychiatry and Behavioral Sciences, Neurobehavioral Research 
      Laboratory, Box #3412, Duke University Medical Center, Durham, NC 27710, USA.
FAU - Levin, Edward D
AU  - Levin ED
LA  - eng
GR  - MH64494/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060323
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Chrna7 protein, rat)
RN  - 0 (Drug Combinations)
RN  - 0 (Nicotinic Antagonists)
RN  - 0 (Receptors, Nicotinic)
RN  - 0 (alpha7 Nicotinic Acetylcholine Receptor)
RN  - 0 (nicotinic receptor alpha4beta2)
RN  - 21019-30-7 (methyllycaconitine)
RN  - 23255-54-1 (Dihydro-beta-Erythroidine)
RN  - X8YN71D5WC (Aconitine)
SB  - IM
MH  - Aconitine/analogs & derivatives/pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Dihydro-beta-Erythroidine/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Combinations
MH  - Female
MH  - Hippocampus/drug effects/*physiology
MH  - Maze Learning/drug effects
MH  - Memory/classification/drug effects/*physiology
MH  - Nicotinic Antagonists/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time/drug effects
MH  - Receptors, Nicotinic/*physiology
MH  - Time Factors
MH  - alpha7 Nicotinic Acetylcholine Receptor
EDAT- 2006/03/25 09:00
MHDA- 2006/07/11 09:00
CRDT- 2006/03/25 09:00
PHST- 2005/05/12 00:00 [received]
PHST- 2005/12/30 00:00 [revised]
PHST- 2006/01/06 00:00 [accepted]
PHST- 2006/03/25 09:00 [pubmed]
PHST- 2006/07/11 09:00 [medline]
PHST- 2006/03/25 09:00 [entrez]
AID - S0006-8993(06)00077-1 [pii]
AID - 10.1016/j.brainres.2006.01.052 [doi]
PST - ppublish
SO  - Brain Res. 2006 Apr 7;1081(1):72-8. doi: 10.1016/j.brainres.2006.01.052. Epub 
      2006 Mar 23.