PMID- 16563725
OWN - NLM
STAT- MEDLINE
DCOM- 20061130
LR  - 20061020
IS  - 0955-2863 (Print)
IS  - 0955-2863 (Linking)
VI  - 17
IP  - 11
DP  - 2006 Nov
TI  - Dietary carbohydrate and cholesterol influence the number of particles and 
      distributions of lipoprotein subfractions in guinea pigs.
PG  - 773-9
AB  - Guinea pigs (n=10/group) were fed one of three diets: a high carbohydrate (CHO) 
      (42% energy), low cholesterol (0.04%) diet (LChHC), a diet with the same amount 
      of CHO but with 0.25% cholesterol (HChHC) or a diet with 11% of energy from CHO 
      and 0.25% cholesterol (HChLC) for 12 weeks. VLDL- and LDL cholesterol (LDL-C) 
      were higher in the HChLC and HChHC groups than in the LChHC group (P<.0001). 
      Lipoprotein subclasses and size were analyzed by nuclear magnetic resonance. 
      Dietary cholesterol (HChHC and HChLC groups) resulted in larger VLDL particles 
      (71.1+/-6.9, 78.9+/-3.33 nm, respectively) than those in the LChHC group 
      (44.3+/-10.8 nm). In addition, there were higher concentrations of the large VLDL 
      (>60 nm) and the medium VLDL (>35 nm) in the high cholesterol groups (P<.01). 
      Similarly, the concentration of the medium (>8.2 nm) and small HDL (>7.2 nm) was 
      higher in the HChHC and HChLC groups (P<.001). In contrast, CHO restriction 
      affected the concentrations of LDL subfractions. The number of total LDL 
      particles was lower in the HChLC (291.3+/-85.0 nmol/L) than in the HChHC group 
      (467.6+/-113.1 nmol/L), indicating that the cholesterol in LDL was distributed in 
      less particles in the former group. The concentrations of medium LDL (>19.8 nm) 
      (98.4+/-90.8) and small LDL (>18 nm) (29.3+/-24.9 nmol/L) were lower in the HChLC 
      group than in the HChHC group (261.8+/-105.8 and 64.9+/-27.9 nmol/L, 
      respectively). These results indicate that dietary cholesterol increased the 
      atherogenicity of both VLDL and HDL while CHO restriction increased the number of 
      large LDL and decreased the concentrations of the more atherogenic smaller LDL 
      subfractions.
FAU - Torres-Gonzalez, Moises
AU  - Torres-Gonzalez M
AD  - Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, 
      USA.
FAU - Volek, Jeff S
AU  - Volek JS
FAU - Sharman, Matthew
AU  - Sharman M
FAU - Contois, John H
AU  - Contois JH
FAU - Fernandez, Maria Luz
AU  - Fernandez ML
LA  - eng
PT  - Journal Article
DEP - 20060203
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Lipoproteins)
SB  - IM
MH  - Animals
MH  - Cholesterol, Dietary/metabolism/*pharmacology
MH  - Dietary Carbohydrates/*pharmacology
MH  - Guinea Pigs
MH  - Lipid Metabolism/drug effects
MH  - Lipoproteins/*metabolism
MH  - Male
MH  - Particle Size
EDAT- 2006/03/28 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/03/28 09:00
PHST- 2005/12/19 00:00 [received]
PHST- 2006/01/05 00:00 [revised]
PHST- 2006/01/06 00:00 [accepted]
PHST- 2006/03/28 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/03/28 09:00 [entrez]
AID - S0955-2863(06)00023-4 [pii]
AID - 10.1016/j.jnutbio.2006.01.004 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2006 Nov;17(11):773-9. doi: 10.1016/j.jnutbio.2006.01.004. Epub 
      2006 Feb 3.