PMID- 16565739
OWN - NLM
STAT- MEDLINE
DCOM- 20060623
LR  - 20061115
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 37
IP  - 10
DP  - 2006 May
TI  - Impact of high-resolution matching in allogeneic unrelated donor stem cell 
      transplantation in Switzerland.
PG  - 909-16
AB  - It is currently unknown what degree of human leukocyte antigen (HLA)-mismatching 
      is acceptable in unrelated donor hematopoietic stem cell transplantation 
      (UD-HSCT). Mismatches at some loci may be more permissive than others. We have 
      analyzed the effect of high-resolution HLA-matching on outcome of all 214 
      consecutive recipients of UD-HSCT carried out in Switzerland. All typing was by 
      the Swiss reference laboratory. Donor-recipient pairs were HLA-10/10 matched 
      (n=130) or mismatched for either HLA-A/-B/-DRB1/multiple loci (n=33; 
      (HLA-A/-B=10); (-DRB1=8); (multiple=15)); HLA-C (n=29) or HLA-DQ/-DRB3 (n=22; 
      (DQ=16); (-DRB1=6)). The median follow-up was 32 months. Survival probabilities 
      (+/-95% confidence interval) at 3 years were 57 (+/-10)% for recipients of HLA 
      10/10-matched transplants, 53 (+/-22)% for recipients of HLA-DQ/-DRB3-mismatched 
      transplants, 44 (+/-20)% for recipients of HLA-C-mismatched transplants and 0% 
      for recipients of transplants mismatched at HLA-A/-B/-DRB1/multiple loci 
      (P<0.0001). In multivariate analyses, HLA compatibility was the variable most 
      significantly associated with survival and treatment-related mortality. We found 
      important differences in survival in recipients of UD-HSCT with best results for 
      transplants from 10/10 matched donors. Single mismatches at HLA-DQ/-DRB3 were 
      well tolerated, mismatches at HLA-C had intermediate results and mismatches at 
      HLA-A/-B/-DRB1/multiple loci resulted in poor survival.
FAU - Chalandon, Y
AU  - Chalandon Y
AD  - Hematology Service, Department of Internal Medicine, University Hospital, Geneva, 
      Switzerland. yves.chalandon@hcuge.ch
FAU - Tiercy, J-M
AU  - Tiercy JM
FAU - Schanz, U
AU  - Schanz U
FAU - Gungor, T
AU  - Gungor T
FAU - Seger, R
AU  - Seger R
FAU - Halter, J
AU  - Halter J
FAU - Helg, C
AU  - Helg C
FAU - Chapuis, B
AU  - Chapuis B
FAU - Gratwohl, A
AU  - Gratwohl A
FAU - Tichelli, A
AU  - Tichelli A
FAU - Nicoloso de Faveri, G
AU  - Nicoloso de Faveri G
FAU - Roosnek, E
AU  - Roosnek E
FAU - Passweg, J R
AU  - Passweg JR
CN  - Swiss Transplant Working Group for Blood and Marrow Transplantation (STABMT)
CN  - Swiss National Donor Registry
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - HLA Antigens/*chemistry
MH  - *Histocompatibility
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Infant
MH  - Living Donors
MH  - Male
MH  - Middle Aged
MH  - Stem Cell Transplantation/*methods
MH  - Switzerland
EDAT- 2006/03/28 09:00
MHDA- 2006/06/24 09:00
CRDT- 2006/03/28 09:00
PHST- 2006/03/28 09:00 [pubmed]
PHST- 2006/06/24 09:00 [medline]
PHST- 2006/03/28 09:00 [entrez]
AID - 1705353 [pii]
AID - 10.1038/sj.bmt.1705353 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2006 May;37(10):909-16. doi: 10.1038/sj.bmt.1705353.