PMID- 16566906
OWN - NLM
STAT- MEDLINE
DCOM- 20060810
LR  - 20231213
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1085
IP  - 1
DP  - 2006 Apr 26
TI  - Effects of melatonin on orphanin FQ/nociceptin-induced hyperalgesia in mice.
PG  - 43-8
AB  - The pain modulatory properties of melatonin (MT) are generally recognized but the 
      detail of the interaction between melatonin and opioid system in pain regulation 
      is not fully understood. The present study was undertaken to investigate the 
      modulatory effect of melatonin (MT) on the hyperalgesic effect of Orphanin 
      FQ/Nociceptin (OFQ/NC, NC), a member of opioid peptide family. 
      Intracerebroventricular (i.c.v.) administration of NC (10 microg/mouse) induced 
      significant hyperalgesic effect in tail-flick test in mice; i.c.v. (5, 10, 50 
      microg/mouse) or intraperitoneal (i.p.) (5, 10, 50 mg/kg) co-injection of 
      melatonin dose-dependently reversed NC-induced hyperalgesia and showed a profound 
      analgesic effect. The antihyperalgesia effect of MT could be significantly 
      antagonized by i.c.v. co-injection of luzindole (10 microg/mouse) (an antagonist 
      of MT receptor) or naloxone (10 microg/mouse) (antagonist of traditional opioid 
      receptor). Taken together, all the results suggested that MT could produce a 
      luzindole and naloxone sensitive reversing effect on NC-induced hyperalgesia at 
      supraspinal and peripheral level in mice. The augmentation effect of MT on the 
      traditional opioid system may be one of the mechanisms of this antihyperalgesia 
      action induced by MT. The present work will help to elucidate the mechanism of 
      the pain modulation effect of MT, and also will help to represent new interesting 
      modulating therapeutic targets for the relief of pain.
FAU - Wang, Ting
AU  - Wang T
AD  - Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou 
      University, 222 Tian Shui South Road, Lanzhou 730000, People's Republic of China.
FAU - Li, Shi-Rong
AU  - Li SR
FAU - Dai, Xu
AU  - Dai X
FAU - Peng, Ya-Li
AU  - Peng YL
FAU - Chen, Qiang
AU  - Chen Q
FAU - Wang, Rui
AU  - Wang R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060329
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Opioid Peptides)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Hyperalgesia/*chemically induced/*drug therapy
MH  - Injections, Intraventricular/methods
MH  - Injections, Subcutaneous/methods
MH  - Male
MH  - Melatonin/*administration & dosage
MH  - Mice
MH  - Opioid Peptides/*administration & dosage
MH  - Pain Measurement/methods
MH  - Nociceptin
EDAT- 2006/03/29 09:00
MHDA- 2006/08/11 09:00
CRDT- 2006/03/29 09:00
PHST- 2005/10/06 00:00 [received]
PHST- 2006/01/31 00:00 [revised]
PHST- 2006/02/02 00:00 [accepted]
PHST- 2006/03/29 09:00 [pubmed]
PHST- 2006/08/11 09:00 [medline]
PHST- 2006/03/29 09:00 [entrez]
AID - S0006-8993(06)00378-7 [pii]
AID - 10.1016/j.brainres.2006.02.006 [doi]
PST - ppublish
SO  - Brain Res. 2006 Apr 26;1085(1):43-8. doi: 10.1016/j.brainres.2006.02.006. Epub 
      2006 Mar 29.