PMID- 16567002
OWN - NLM
STAT- MEDLINE
DCOM- 20060629
LR  - 20220318
IS  - 0165-2427 (Print)
IS  - 0165-2427 (Linking)
VI  - 111
IP  - 3-4
DP  - 2006 Jun 15
TI  - Modulation of canine immunosenescence by life-long caloric restriction.
PG  - 287-99
AB  - Caloric restriction (CR) has been shown to retard immunosenescence and to extend 
      median and maximum life span in rodent species. Longitudinal effects of CR on the 
      canine immune system are presented in this report. A group of 48 Labrador 
      Retrievers, divided at weaning into weight- and sex-matched pairs, were 
      maintained on a diet restriction protocol from age 8 weeks until death. Each 
      restricted dog received 75% of the total food consumed by its control-fed pair 
      mate. Immune parameters were monitored from 4 to 13 years. CR retarded 
      age-related declines in both lymphoproliferative responses and absolute numbers 
      of lymphocytes and the T, CD4, and CD8-cell subsets. In females, CR attenuated 
      the age-related increase in T-cell percentages and marginally retarded the 
      age-related increase in memory cell percentages. Age-related changes in B-cell 
      percentages and numbers were augmented by CR. No direct effect of CR on 
      phagocytic activity of PMN, antibody production or NK cell activity, was 
      observed. Lower lymphoproliferative responses, lower numbers of lymphocytes, T, 
      CD4 and CD8 cells, lower CD8 percentages and higher B-cell percentages were all 
      found to be significantly associated with a decreased likelihood of survival in 
      these dogs.
FAU - Greeley, Elizabeth H
AU  - Greeley EH
AD  - Department of Pathobiology, University of Illinois, Urbana, IL 61802, USA. 
      egreeley@uiuc.edu
FAU - Spitznagel, Edward
AU  - Spitznagel E
FAU - Lawler, Dennis F
AU  - Lawler DF
FAU - Kealy, Richard D
AU  - Kealy RD
FAU - Segre, Mariangela
AU  - Segre M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20060329
PL  - Netherlands
TA  - Vet Immunol Immunopathol
JT  - Veterinary immunology and immunopathology
JID - 8002006
RN  - 0 (Antibodies)
RN  - 0 (Mitogens)
SB  - IM
MH  - Aging/*immunology
MH  - Animals
MH  - Antibodies/blood
MH  - Caloric Restriction/*veterinary
MH  - Dogs/*immunology
MH  - Female
MH  - Flow Cytometry/veterinary
MH  - Killer Cells, Natural/immunology
MH  - Leukocytes, Mononuclear/cytology/*immunology
MH  - Longitudinal Studies
MH  - Lymphocyte Activation
MH  - Lymphocyte Count/veterinary
MH  - Lymphocyte Subsets/immunology
MH  - Male
MH  - Mitogens/immunology
MH  - Phagocytosis/immunology
MH  - Proportional Hazards Models
EDAT- 2006/03/29 09:00
MHDA- 2006/06/30 09:00
CRDT- 2006/03/29 09:00
PHST- 2005/07/25 00:00 [received]
PHST- 2006/02/09 00:00 [accepted]
PHST- 2006/03/29 09:00 [pubmed]
PHST- 2006/06/30 09:00 [medline]
PHST- 2006/03/29 09:00 [entrez]
AID - S0165-2427(06)00045-6 [pii]
AID - 10.1016/j.vetimm.2006.02.002 [doi]
PST - ppublish
SO  - Vet Immunol Immunopathol. 2006 Jun 15;111(3-4):287-99. doi: 
      10.1016/j.vetimm.2006.02.002. Epub 2006 Mar 29.