PMID- 16569356
OWN - NLM
STAT- MEDLINE
DCOM- 20060622
LR  - 20061115
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 19
IP  - 1
DP  - 2006 Jan-Mar
TI  - Altered vessel signalling molecules in subjects with Downs syndrome.
PG  - 181-5
AB  - Downs syndrome (DS) is the most frequent human chromosomal abnormality and is 
      associated with mental retardation. Some evidence indicates that certain 
      inflammatory molecules may be increased in DS. Proinflammatory and vasoactive 
      molecules in the blood of non demented subjects with DS were measured in the 
      present investigation. Plasma levels of interleukin-6 (IL-6), vascular 
      endothelial growth factor (VEGF), monocyte chemoattractant protein-1 (MCP-1) and 
      C reactive protein (CRP) were measured in child (2-14 years), adult (20-50 yrs) 
      and elderly (> 60 yrs) DS subjects. Increased plasma levels of IL-6 and MCP-1 
      were present in DS. Plasma levels of VEGF were increased only in DS adults. 
      Positive linear correlation between IL-6 and MCP-1 levels was present. However, 
      no subclinical inflammation was apparent in DS, since neopterin and CRP levels 
      were within the normal range. An altered regulation of these molecules might 
      interfere with some processes involved in cognitive performances of DS subjects.
FAU - Licastro, F
AU  - Licastro F
AD  - Department of Experimental Pathology, University of Bologna, Via S. Giacomo 14, 
      40126 Bologna, Italy. licastro@alma.unibo.it
FAU - Chiappelli, M
AU  - Chiappelli M
FAU - Porcellini, E
AU  - Porcellini E
FAU - Trabucchi, M
AU  - Trabucchi M
FAU - Marocchi, A
AU  - Marocchi A
FAU - Corsi, M M
AU  - Corsi MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aging/metabolism
MH  - C-Reactive Protein/metabolism
MH  - Chemokine CCL2/blood
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Down Syndrome/*metabolism
MH  - Female
MH  - Humans
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Vascular Endothelial Growth Factor A/blood
EDAT- 2006/03/30 09:00
MHDA- 2006/06/23 09:00
CRDT- 2006/03/30 09:00
PHST- 2006/03/30 09:00 [pubmed]
PHST- 2006/06/23 09:00 [medline]
PHST- 2006/03/30 09:00 [entrez]
AID - 18 [pii]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2006 Jan-Mar;19(1):181-5.