PMID- 16569464
OWN - NLM
STAT- MEDLINE
DCOM- 20070322
LR  - 20220310
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 28
IP  - 4
DP  - 2007 Apr
TI  - Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in 
      Alzheimer disease.
PG  - 533-6
AB  - Tumor necrosis factor-alpha (TNF-alpha) and insulin-like growth factor-I (IGF-I) 
      have been involved in the pathogenesis of Alzheimer's disease (AD) as neurotoxic 
      and survival factors, respectively. Recent experimental studies suggest that the 
      signalling pathways of TNF-alpha and IGF-I are functionally interrelated. In 
      order to investigate the possible interaction of TNF-alpha and IGF-I in AD and 
      mild cognitive impairment (MCI), the serum levels of total IGF-I, free IGF-I and 
      TNF-alpha were determined in 141 AD patients, 56 MCI cases and 30 controls. As 
      compared with controls, AD patients showed increased TNF-alpha and decreased 
      IGF-I levels in serum, as well as a significant negative correlation between 
      TNF-alpha and free IGF-I values. MCI patients also exhibited significantly higher 
      TNF-alpha levels than controls. The present results suggest that increased 
      TNF-alpha levels are involved in the pathogenesis of AD and MCI, and might 
      antagonize the neurotrophic activity of IGF-I in these medical conditions. In 
      addition, the combined determination of TNF-alpha and IGF-I might be useful to 
      monitor anti-inflammatory and/or neurotrophic drug effects in AD.
FAU - Alvarez, Anton
AU  - Alvarez A
AD  - EuroEspes Biomedical Research Center, 15166 A Coruna, Spain. xantonal@yahoo.es 
      <xantonal@yahoo.es>
FAU - Cacabelos, Ramon
AU  - Cacabelos R
FAU - Sanpedro, Carolina
AU  - Sanpedro C
FAU - Garcia-Fantini, Manuel
AU  - Garcia-Fantini M
FAU - Aleixandre, Manuel
AU  - Aleixandre M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060329
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*metabolism
MH  - Case-Control Studies
MH  - Cognition Disorders/metabolism
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Statistics as Topic
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2006/03/30 09:00
MHDA- 2007/03/23 09:00
CRDT- 2006/03/30 09:00
PHST- 2005/11/22 00:00 [received]
PHST- 2006/02/17 00:00 [revised]
PHST- 2006/02/18 00:00 [accepted]
PHST- 2006/03/30 09:00 [pubmed]
PHST- 2007/03/23 09:00 [medline]
PHST- 2006/03/30 09:00 [entrez]
AID - S0197-4580(06)00081-9 [pii]
AID - 10.1016/j.neurobiolaging.2006.02.012 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2007 Apr;28(4):533-6. doi: 10.1016/j.neurobiolaging.2006.02.012. 
      Epub 2006 Mar 29.