PMID- 16571410
OWN - NLM
STAT- MEDLINE
DCOM- 20090611
LR  - 20060330
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 11
DP  - 2005 Nov
TI  - Impact of HLA-C and Bw epitopes disparity on liver transplantation outcome.
PG  - 1099-105
AB  - The occurrence of graft rejection episodes after orthotopic liver transplantation 
      (OLT) despite the use of immunosuppressive drugs designed to suppress T 
      lymphocyte functions, indicates the involvement of other types of cells in this 
      process. The activity of natural killer cells and their killer 
      immunoglobulin-like receptors (KIR) is regulated by human leukocyte antigen (HLA) 
      class I determinants; C and Bw epitopes. Because recipient/donor pairs are 
      usually HLA mismatched, recipient natural killer alloreactivity may be the 
      mediating factor in rejection. In this retrospective study, we have analyzed 
      rejection occurrence and outcome in 66 OLT recipients, 42 with and 24 without C 
      or Bw epitope disparity in the rejection direction. Recipients transplanted from 
      donors with no C epitope disparity had significantly fewer rejection episodes in 
      the first year after transplantation compared with recipients transplanted across 
      C epitope disparity (p = 0.0002). Moreover, this effect was more pronounced when 
      the outcome was analyzed in OLT recipients across negative crossmatching for the 
      anti-HLA class I and II antibodies. In contrast, Bw epitope disparity did not 
      affect the outcome. In conclusion, C epitopes disparity between recipients and 
      donors in the rejection direction appears to influence posttransplant liver 
      outcome. This finding may be helpful in the choice of appropriate liver donor and 
      planning immune suppression.
FAU - Bishara, Amal
AU  - Bishara A
AD  - Tissue Typing Unit, Division of Medicine, Hadassah-Hebrew University Medical 
      Center, Jerusalem, Israel. anal@hadassah.org.il
FAU - Brautbar, Chaim
AU  - Brautbar C
FAU - Zamir, Gideon
AU  - Zamir G
FAU - Eid, Ahmed
AU  - Eid A
FAU - Safadi, Rifaat
AU  - Safadi R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060315
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Epitopes)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Isoantibodies)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adult
MH  - Epitopes/adverse effects/*immunology
MH  - Female
MH  - Graft Rejection/complications/*immunology
MH  - HLA-C Antigens/adverse effects/*immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Isoantibodies/adverse effects/classification/physiology
MH  - Killer Cells, Natural/immunology/metabolism
MH  - Liver Transplantation/*adverse effects/*immunology
MH  - Male
MH  - Middle Aged
MH  - Receptors, KIR/metabolism
MH  - Treatment Outcome
EDAT- 2006/03/31 09:00
MHDA- 2009/06/12 09:00
CRDT- 2006/03/31 09:00
PHST- 2005/05/24 00:00 [received]
PHST- 2005/09/10 00:00 [revised]
PHST- 2005/10/10 00:00 [accepted]
PHST- 2006/03/31 09:00 [pubmed]
PHST- 2009/06/12 09:00 [medline]
PHST- 2006/03/31 09:00 [entrez]
AID - S0198-8859(05)00453-2 [pii]
AID - 10.1016/j.humimm.2005.10.016 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 Nov;66(11):1099-105. doi: 10.1016/j.humimm.2005.10.016. Epub 
      2006 Mar 15.