PMID- 1657220
OWN - NLM
STAT- MEDLINE
DCOM- 19911217
LR  - 20190815
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 30
IP  - 5
DP  - 1991 Sep 1
TI  - The agonist-stimulated accumulation of inositol phosphates is attenuated in 
      neutrophils from male patients under chronic lithium therapy.
PG  - 443-51
AB  - Neutrophils from 22 patients (11 men, 11 women) under chronic lithium therapy and 
      from 22 age- and sex-matched healthy controls were assessed for the activity of 
      the agonist-stimulated inositol-phospholipid second messenger-producing system. 
      [3H]inositol-labeled cells were stimulated with the chemotactic peptide 
      formylmethionylleucylphenyl-alanin (fMLP). The fMLP-evoked increase in the 
      accumulation of [3H]inositol phosphates was significantly attenuated in 
      neutrophils from chronically lithium-treated male but not female patients. 
      Furthermore, the fMLP-stimulated accumulation of inositol phosphates was 
      attenuated in neutrophils from male volunteers, when the labeling of the cells 
      with [3H]inositol was performed in the presence of 1mM Li (4 hr, 37 degrees C). 
      However, the presence of lithium ions during the labeling did not further reduce 
      the already diminished response of neutrophils from patients under lithium 
      therapy. These results suggest that lithium treatment induces an inhibition of 
      the agonist-evoked breakdown of inositol phospholipids in human cells, as already 
      shown for rat brain slices.
FAU - Greil, W
AU  - Greil W
AD  - Department of Psychiatry, University of Munich, F.R.G.
FAU - Steber, R
AU  - Steber R
FAU - van Calker, D
AU  - van Calker D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Inositol Phosphates)
RN  - 0 (Phosphatidylinositols)
RN  - 2BMD2GNA4V (Lithium Carbonate)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bipolar Disorder/*drug therapy/physiopathology/psychology
MH  - Chronic Disease
MH  - Depressive Disorder/*drug therapy/physiopathology/psychology
MH  - Female
MH  - Humans
MH  - Inositol Phosphates/*blood
MH  - Lithium Carbonate/pharmacokinetics/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - N-Formylmethionine Leucyl-Phenylalanine/metabolism
MH  - Neutrophils/*drug effects/physiology
MH  - Phosphatidylinositols/blood
MH  - Psychotic Disorders/*drug therapy/physiopathology/psychology
MH  - Second Messenger Systems/drug effects/physiology
EDAT- 1991/09/01 00:00
MHDA- 1991/09/01 00:01
CRDT- 1991/09/01 00:00
PHST- 1991/09/01 00:00 [pubmed]
PHST- 1991/09/01 00:01 [medline]
PHST- 1991/09/01 00:00 [entrez]
AID - 0006-3223(91)90305-6 [pii]
AID - 10.1016/0006-3223(91)90305-6 [doi]
PST - ppublish
SO  - Biol Psychiatry. 1991 Sep 1;30(5):443-51. doi: 10.1016/0006-3223(91)90305-6.