PMID- 16572855
OWN - NLM
STAT- MEDLINE
DCOM- 20090723
LR  - 20060331
IS  - 1000-3061 (Print)
IS  - 1000-3061 (Linking)
VI  - 22
IP  - 1
DP  - 2006 Jan
TI  - [Modelling a penicillin fed-batch fermentation using least squares support vector 
      machines].
PG  - 144-9
AB  - The biochemical processes are usually characterized as seriously time varying and 
      nonlinear dynamic systems. Building their first-principle models are very costly 
      and difficult due to the absence of inherent mechanism and efficient on-line 
      sensors. Furthermore, these detailed and complicated models do not necessary 
      guarantee a good performance in practice. An approach via least squares support 
      vector machines (LS-SVM) based on Pensim simulator is proposed for modelling the 
      penicillin fed-batch fermentation process, and the adjustment strategy for 
      parameters of LS-SVM is presented. Based on the proposed modelling method, the 
      predictive models of penicillin concentration, biomass concentration and 
      substrate concentration are obtained by using very limited on-line measurements. 
      The results show that the models established are more accurate and efficient, and 
      suffice for the requirements of control and optimization for biochemical 
      processes.
FAU - Liu, Yi
AU  - Liu Y
AD  - National Laboratory of Industrial Control Technology, Institute of Industrial 
      Process Control, Zhejiang University, Hangzhou 310027, China.
FAU - Wang, Hai-Qing
AU  - Wang HQ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sheng Wu Gong Cheng Xue Bao
JT  - Sheng wu gong cheng xue bao = Chinese journal of biotechnology
JID - 9426463
RN  - 0 (Penicillins)
SB  - IM
MH  - Biomass
MH  - Computer Simulation
MH  - *Fermentation
MH  - *Least-Squares Analysis
MH  - *Models, Biological
MH  - Models, Statistical
MH  - Nonlinear Dynamics
MH  - Penicillins/analysis/*biosynthesis
EDAT- 2006/04/01 09:00
MHDA- 2009/07/25 09:00
CRDT- 2006/04/01 09:00
PHST- 2006/04/01 09:00 [pubmed]
PHST- 2009/07/25 09:00 [medline]
PHST- 2006/04/01 09:00 [entrez]
PST - ppublish
SO  - Sheng Wu Gong Cheng Xue Bao. 2006 Jan;22(1):144-9.