PMID- 16573557
OWN - NLM
STAT- MEDLINE
DCOM- 20060511
LR  - 20231213
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 67
IP  - 3
DP  - 2006 Mar
TI  - HLA-E and immunobiology of pregnancy.
PG  - 207-13
AB  - Recently, it has been suggested that non-classical antigens such as human 
      leukocyte antigen (HLA)-G and HLA-E may interact with KIR receptors of NK cells 
      which results into downregulation of immune response and helps in the maintenance 
      of pregnancy. In the present study, we have investigated HLA-E polymorphism in 
      normal fertile women and recurrent spontaneous aborters to assess the effect of 
      HLA-E alleles on the success of pregnancy. Allele E*0101 was found to be 
      significantly higher in patients with recurrent spontaneous abortion (chi(2) = 
      4.097 and P = 0.0430). Differential expression, peptide affinity, and stability 
      of E*0101 may be one of the reasons.
FAU - Tripathi, P
AU  - Tripathi P
AD  - Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical 
      Sciences, Lucknow, Uttar Pradhesh, India.
FAU - Naik, S
AU  - Naik S
FAU - Agrawal, S
AU  - Agrawal S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Codon)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Abortion, Habitual/genetics/*immunology
MH  - Alleles
MH  - Codon
MH  - Exons
MH  - Female
MH  - Gene Frequency
MH  - HLA Antigens/chemistry/*genetics/immunology
MH  - Histocompatibility Antigens Class I/chemistry/*genetics/immunology
MH  - Humans
MH  - Models, Molecular
MH  - Mutation
MH  - Nucleic Acid Amplification Techniques
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Pregnancy Trimester, First
MH  - Receptors, Immunologic/immunology/metabolism
MH  - Receptors, KIR
MH  - HLA-E Antigens
EDAT- 2006/04/01 09:00
MHDA- 2006/05/12 09:00
CRDT- 2006/04/01 09:00
PHST- 2006/04/01 09:00 [pubmed]
PHST- 2006/05/12 09:00 [medline]
PHST- 2006/04/01 09:00 [entrez]
AID - TAN550 [pii]
AID - 10.1111/j.1399-0039.2005.00550.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2006 Mar;67(3):207-13. doi: 10.1111/j.1399-0039.2005.00550.x.