PMID- 16573618
OWN - NLM
STAT- MEDLINE
DCOM- 20060822
LR  - 20131121
IS  - 1397-3142 (Print)
IS  - 1397-3142 (Linking)
VI  - 10
IP  - 2
DP  - 2006 Mar
TI  - Assessment of nephrotoxicity of high-cumulative dose of liposomal amphotericin B 
      in a pediatric patient who underwent allogeneic bone marrow transplantation.
PG  - 255-8
AB  - We describe a 9-yr-old boy who received the highest cumulative dose so far 
      reported of liposomal amphotericin B. The patient underwent an allogeneic bone 
      marrow transplantation (BMT) for adrenoleucodystrophy, after a conditioning 
      regimen with busulfan, thiothepa and cyclophosphamide. Rabbit antithymoglobulin, 
      cyclosporin and prednisone were used as prophylaxis against graft vs. host 
      disease (GVHD). Post-transplant Epstein-Bar-virus-related lymphoma was diagnosed 
      on day +68 and was treated with donor-derived lymphocytes. The patient developed 
      a severe form of GVHD, and a progressive worsening of his neurological status 
      because of progression of his underlying disease. Death from septic shock 
      occurred 23 months after BMT. During prolonged hospitalization, 19,750 mg of 
      liposomal amphotericin B, about 1000 mg/kg, were given for prophylactic or 
      empirical therapeutic purposes without significant nephrotoxicity. This case 
      suggests that liposomal amphotericin B is safe and well-tolerated even if is 
      administered for long periods and a cumulative dose fivefold greater than the 
      nephrotoxic threshold of amphotericin B deoxycholate is achieved.
FAU - Cesaro, Simone
AU  - Cesaro S
AD  - Department of Pediatrics, Clinic of Pediatric Hematology Oncology, University of 
      Padova, Padova, Italy. simone.cesaro@unipd.it
FAU - Zignol, Matteo
AU  - Zignol M
FAU - Burlina, Alberto B
AU  - Burlina AB
FAU - Tridello, Gloria
AU  - Tridello G
FAU - Visintin, Gianluca
AU  - Visintin G
FAU - Messina, Chiara
AU  - Messina C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Denmark
TA  - Pediatr Transplant
JT  - Pediatric transplantation
JID - 9802574
RN  - 0 (Antifungal Agents)
RN  - 0 (Liposomes)
RN  - 0 (liposomal amphotericin B)
RN  - 7XU7A7DROE (Amphotericin B)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adrenoleukodystrophy/surgery
MH  - Amphotericin B/administration & dosage/*adverse effects
MH  - Antifungal Agents/administration & dosage/*adverse effects
MH  - *Bone Marrow Transplantation/immunology
MH  - Candidiasis/prevention & control
MH  - Child
MH  - Creatinine/blood
MH  - Disease Progression
MH  - Epstein-Barr Virus Infections
MH  - Fatal Outcome
MH  - Graft vs Host Disease/etiology/prevention & control
MH  - Humans
MH  - Kidney/drug effects
MH  - Kidney Diseases/*chemically induced
MH  - Liposomes
MH  - Lymphoma/therapy/virology
MH  - Male
MH  - Pseudomonas Infections/prevention & control
MH  - Shock, Septic/microbiology
MH  - T-Lymphocytes, Cytotoxic
MH  - Transplantation Conditioning
EDAT- 2006/04/01 09:00
MHDA- 2006/08/23 09:00
CRDT- 2006/04/01 09:00
PHST- 2006/04/01 09:00 [pubmed]
PHST- 2006/08/23 09:00 [medline]
PHST- 2006/04/01 09:00 [entrez]
AID - PTR434 [pii]
AID - 10.1111/j.1399-3046.2005.00434.x [doi]
PST - ppublish
SO  - Pediatr Transplant. 2006 Mar;10(2):255-8. doi: 10.1111/j.1399-3046.2005.00434.x.