PMID- 16574059
OWN - NLM
STAT- MEDLINE
DCOM- 20060929
LR  - 20161126
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1757
IP  - 5-6
DP  - 2006 May-Jun
TI  - Mitochondrial oxidative stress, aging and caloric restriction: the protein and 
      methionine connection.
PG  - 496-508
AB  - Caloric restriction (CR) decreases aging rate and mitochondrial ROS (MitROS) 
      production and oxidative stress in rat postmitotic tissues. Low levels of these 
      parameters are also typical traits of long-lived mammals and birds. However, it 
      is not known what dietary components are responsible for these changes during CR. 
      It was recently observed that 40% protein restriction without strong CR also 
      decreases MitROS generation and oxidative stress. This is interesting because 
      protein restriction also increases maximum longevity (although to a lower extent 
      than CR) and is a much more practicable intervention for humans than CR. 
      Moreover, it was recently found that 80% methionine restriction substituting it 
      for l-glutamate in the diet also decreases MitROS generation in rat liver. Thus, 
      methionine restriction seems to be responsible for the decrease in ROS production 
      observed in caloric restriction. This is interesting because it is known that 
      exactly that procedure of methionine restriction also increases maximum 
      longevity. Moreover, recent data show that methionine levels in tissue proteins 
      negatively correlate with maximum longevity in mammals and birds. All these 
      suggest that lowering of methionine levels is involved in the control of 
      mitochondrial oxidative stress and vertebrate longevity by at least two different 
      mechanisms: decreasing the sensitivity of proteins to oxidative damage, and 
      lowering of the rate of ROS generation at mitochondria.
FAU - Pamplona, Reinald
AU  - Pamplona R
AD  - Department of Basic Medical Sciences, University of Lleida, Lleida 25008, Spain.
FAU - Barja, Gustavo
AU  - Barja G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20060224
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (DNA, Mitochondrial)
RN  - 0 (Reactive Oxygen Species)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Aging/metabolism/*physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - DNA, Mitochondrial/metabolism
MH  - *Diet, Protein-Restricted
MH  - Humans
MH  - Lipid Metabolism
MH  - Longevity
MH  - Methionine/*metabolism
MH  - Mitochondria/*metabolism
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
RF  - 156
EDAT- 2006/04/01 09:00
MHDA- 2006/09/30 09:00
CRDT- 2006/04/01 09:00
PHST- 2005/11/22 00:00 [received]
PHST- 2006/01/10 00:00 [revised]
PHST- 2006/01/28 00:00 [accepted]
PHST- 2006/04/01 09:00 [pubmed]
PHST- 2006/09/30 09:00 [medline]
PHST- 2006/04/01 09:00 [entrez]
AID - S0005-2728(06)00022-3 [pii]
AID - 10.1016/j.bbabio.2006.01.009 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2006 May-Jun;1757(5-6):496-508. doi: 
      10.1016/j.bbabio.2006.01.009. Epub 2006 Feb 24.