PMID- 16574253
OWN - NLM
STAT- MEDLINE
DCOM- 20061011
LR  - 20131121
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 170
IP  - 1
DP  - 2006 Jun 3
TI  - Intracerebroventricular injection of L-serine analogs and derivatives induces 
      sedative and hypnotic effects under an acute stressful condition in neonatal 
      chicks.
PG  - 71-7
AB  - Four experiments were conducted to clarify the central functions of L-serine and 
      its analogs on an acute stressful condition. Intracerebroventricular (i.c.v.) 
      injection of L-serine (0.21, 0.42 and 0.84 micromol) attenuated stress responses 
      in a dose-dependent fashion, as well as induced sleep, in Experiment 1. The 
      effects of L- and D-serine in Experiment 2, those of L-serine, phosphoserine, 
      acetylserine and L-cysteine in Experiment 3 and those of L-serine, glycine and 
      lysophosphatidylserine in Experiment 4 were compared at an equimolar basis (0.84 
      micromol). D-Serine, proposed as an endogenous agonist of N-methyl-D-aspatate 
      (NMDA) receptor, did not have sedative and hypnotic effects as observed with 
      L-serine. In contrast, all the analogs and derivatives of L-serine had a sedative 
      effect, although with a different manner in several behavioral markers of stress 
      such as spontaneous activity and distress vocalizations. No significant changes 
      in plasma corticosterone concentration were observed in any experiment. Taken 
      together, the i.c.v. injection of L-serine analogs and its derivatives have 
      sedative and hypnotic effects under an acute stressful condition, which does not 
      involve the hypothalamic-pituitary-adrenal axis. In conclusion, L-serine may be 
      effective in improving anxiety or sleep disorders induced by psychological 
      stressor.
FAU - Asechi, Mari
AU  - Asechi M
AD  - Laboratory of Advanced Animal and Marine Bioresources, Graduate School of 
      Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Tomonaga, Shozo
AU  - Tomonaga S
FAU - Tachibana, Tetsuya
AU  - Tachibana T
FAU - Han, Li
AU  - Han L
FAU - Hayamizu, Kohsuke
AU  - Hayamizu K
FAU - Denbow, D Michael
AU  - Denbow DM
FAU - Furuse, Mitsuhiro
AU  - Furuse M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060329
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 452VLY9402 (Serine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Arousal/*drug effects
MH  - Brain/drug effects
MH  - Chickens
MH  - Dose-Response Relationship, Drug
MH  - Hypnotics and Sedatives/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Motor Activity/drug effects
MH  - Posture
MH  - Receptors, N-Methyl-D-Aspartate/agonists
MH  - Serine/*analogs & derivatives/*pharmacology
MH  - Sleep/drug effects
MH  - Social Environment
MH  - Stress, Psychological/*complications
MH  - Vocalization, Animal/drug effects
EDAT- 2006/04/01 09:00
MHDA- 2006/10/13 09:00
CRDT- 2006/04/01 09:00
PHST- 2005/10/13 00:00 [received]
PHST- 2006/01/31 00:00 [revised]
PHST- 2006/02/07 00:00 [accepted]
PHST- 2006/04/01 09:00 [pubmed]
PHST- 2006/10/13 09:00 [medline]
PHST- 2006/04/01 09:00 [entrez]
AID - S0166-4328(06)00112-4 [pii]
AID - 10.1016/j.bbr.2006.02.005 [doi]
PST - ppublish
SO  - Behav Brain Res. 2006 Jun 3;170(1):71-7. doi: 10.1016/j.bbr.2006.02.005. Epub 
      2006 Mar 29.