PMID- 16574712
OWN - NLM
STAT- MEDLINE
DCOM- 20061018
LR  - 20191210
IS  - 0269-8811 (Print)
IS  - 0269-8811 (Linking)
VI  - 20
IP  - 3
DP  - 2006 May
TI  - MDMA polydrug users show process-specific central executive impairments coupled 
      with impaired social and emotional judgement processes.
PG  - 385-8
AB  - In recent years working memory deficits have been reported in users of MDMA 
      (3,4-methylenedioxymethamphetamine, ecstasy). The current study aimed to assess 
      the impact of MDMA use on three separate central executive processes (set 
      shifting, inhibition and memory updating) and also on "prefrontal" mediated 
      social and emotional judgement processes. Fifteen polydrug ecstasy users and 15 
      polydrug non-ecstasy user controls completed a general drug use questionnaire, 
      the Brixton Spatial Anticipation task (set shifting), Backward Digit Span 
      procedure (memory updating), Inhibition of Return (inhibition), an emotional 
      intelligence scale, the Tromso Social Intelligence Scale and the Dysexecutive 
      Questionnaire (DEX). Compared with MDMA-free polydrug controls, MDMA polydrug 
      users showed impairments in set shifting and memory updating, and also in social 
      and emotional judgement processes. The latter two deficits remained significant 
      after controlling for other drug use. These data lend further support to the 
      proposal that cognitive processes mediated by the prefrontal cortex may be 
      impaired by recreational ecstasy use.
FAU - Reay, J L
AU  - Reay JL
AD  - Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria 
      University, Newcastle upon Tyne, UK.
FAU - Hamilton, C
AU  - Hamilton C
FAU - Kennedy, D O
AU  - Kennedy DO
FAU - Scholey, A B
AU  - Scholey AB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
RN  - 0 (Illicit Drugs)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alcoholism/diagnosis/psychology
MH  - Amphetamine-Related Disorders/*diagnosis/psychology
MH  - Attention/drug effects
MH  - Cocaine-Related Disorders/diagnosis/psychology
MH  - Cognition Disorders/*chemically induced/diagnosis/psychology
MH  - Drug Interactions
MH  - *Emotions/drug effects
MH  - Female
MH  - Humans
MH  - Illicit Drugs/*adverse effects
MH  - Inhibition, Psychological
MH  - *Judgment
MH  - Male
MH  - Marijuana Abuse/diagnosis/psychology
MH  - Mental Recall/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - *Neuropsychological Tests
MH  - Prefrontal Cortex/drug effects
MH  - Problem Solving/drug effects
MH  - Smoking/adverse effects
MH  - *Social Perception
MH  - Substance-Related Disorders/*diagnosis/psychology
EDAT- 2006/04/01 09:00
MHDA- 2006/10/19 09:00
CRDT- 2006/04/01 09:00
PHST- 2006/04/01 09:00 [pubmed]
PHST- 2006/10/19 09:00 [medline]
PHST- 2006/04/01 09:00 [entrez]
AID - 20/3/385 [pii]
AID - 10.1177/0269881106063269 [doi]
PST - ppublish
SO  - J Psychopharmacol. 2006 May;20(3):385-8. doi: 10.1177/0269881106063269.