PMID- 1657776
OWN - NLM
STAT- MEDLINE
DCOM- 19911226
LR  - 20190722
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 18
IP  - 5 Suppl
DP  - 1991 Nov
TI  - Effects of hypertension and aging on platelet-derived growth factor and 
      platelet-derived growth factor receptor expression in rat aorta and heart.
PG  - III93-9
AB  - Previous investigations have demonstrated certain similarities in the cellular 
      changes occurring in the arterial wall in response to hypertension and aging. We 
      undertook the current studies to examine the expression of platelet-derived 
      growth factor (PDGF) receptors and ligands and transforming growth factor-beta 1 
      (TGF-beta 1) in aorta and heart of spontaneously hypertensive rats (SHRs), 
      Wistar-Kyoto (WKY) controls, and Wistar rats studied at ages ranging from 5 to 40 
      weeks. A progressive increase with age in aortic steady-state messenger RNA 
      (mRNA) levels of the receptor for the B chain of PDGF (PDGF-r beta) was present 
      in all three strains but was greatest in the SHR. The aortic expression of PDGF A 
      or B ligands as well as of the PDGF-r alpha-receptor was not significantly 
      influenced by age or blood pressure. In contrast, in the heart of the SHR and WKY 
      rat, there was an age-related decrease in expression of both PDGF receptors and 
      of the PDGF B chain. Hypertension and aging were associated with increases in 
      steady-state mRNA for TGF-beta 1 in aorta, but in the heart, reductions again 
      were observed. These studies indicate that both hypertension and aging increase 
      the in vivo expression of PDGF-r beta and TGF-beta 1 in aortic tissue. Such 
      changes might be functionally significant and provide autocrine or paracrine 
      mechanisms for regulation of cellular growth in the arterial wall in response to 
      these conditions. The findings also provide further support for the concept that 
      hypertension accelerates the arterial changes associated with aging.
FAU - Sarzani, R
AU  - Sarzani R
AD  - Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 
      02118.
FAU - Arnaldi, G
AU  - Arnaldi G
FAU - Takasaki, I
AU  - Takasaki I
FAU - Brecher, P
AU  - Brecher P
FAU - Chobanian, A V
AU  - Chobanian AV
LA  - eng
GR  - HL-18318/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 0 (Fibronectins)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Transforming Growth Factor beta)
RN  - EC 2.7.10.1 (Receptors, Platelet-Derived Growth Factor)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Aorta/*metabolism
MH  - Fibronectins/biosynthesis
MH  - Gene Expression Regulation
MH  - Hypertension/*metabolism
MH  - Male
MH  - Myocardium/*metabolism
MH  - Platelet-Derived Growth Factor/*genetics
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred Strains
MH  - Rats, Inbred WKY
MH  - Receptors, Cell Surface/*genetics
MH  - Receptors, Platelet-Derived Growth Factor
MH  - Transforming Growth Factor beta/genetics
EDAT- 1991/11/01 00:00
MHDA- 1991/11/01 00:01
CRDT- 1991/11/01 00:00
PHST- 1991/11/01 00:00 [pubmed]
PHST- 1991/11/01 00:01 [medline]
PHST- 1991/11/01 00:00 [entrez]
AID - 10.1161/01.hyp.18.5_suppl.iii93 [doi]
PST - ppublish
SO  - Hypertension. 1991 Nov;18(5 Suppl):III93-9. doi: 10.1161/01.hyp.18.5_suppl.iii93.