PMID- 16580268
OWN - NLM
STAT- MEDLINE
DCOM- 20060619
LR  - 20191210
IS  - 1570-0232 (Print)
IS  - 1570-0232 (Linking)
VI  - 835
IP  - 1-2
DP  - 2006 May 1
TI  - A validated gas chromatographic-electron impact ionization mass spectrometric 
      method for methylenedioxymethamphetamine (MDMA), methamphetamine and metabolites 
      in oral fluid.
PG  - 90-9
AB  - An analytical method to simultaneously quantify amphetamine (AMP), 
      methamphetamine (MAMP), methylenedioxymethamphetamine (MDMA), 
      methylenedioxyamphetamine (MDA), methylenedioxyethylamphetamine (MDEA), 
      3-hydroxy-4-methoxy-methamphetamine (HMMA) and 3-hydroxy-4-methoxy-amphetamine 
      (HMA) in oral fluid is presented. Four hundred microlitres of oral fluid 
      collected via expectoration was extracted by solid phase extraction. GC/MS-EI 
      with selected ion monitoring (SIM) yielded linear curves 5-250 ng/mL for AMP, 
      MAMP, MDMA and MDEA, 5-500 ng/mL for MDA and 25-1,000 ng/mL for HMA and HMMA. 
      Recoveries were greater than 85%, accuracy 87-104%, and precision less than 8.3% 
      coefficient of variation. This assay will be used to investigate distribution of 
      sympathomimetic amines into human oral fluid following controlled drug 
      administration.
FAU - Scheidweiler, Karl B
AU  - Scheidweiler KB
AD  - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on 
      Drug Abuse, National Institutes of Health, 5500 Nathan Shock Dr., Baltimore, MD 
      21224, USA.
FAU - Huestis, Marilyn A
AU  - Huestis MA
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Validation Study
DEP - 20060331
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Chromatography, Gas/*methods
MH  - Humans
MH  - Methamphetamine/*analysis/*metabolism
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis/*metabolism
MH  - Saliva/*chemistry
MH  - Sensitivity and Specificity
MH  - Spectrometry, Mass, Electrospray Ionization/*methods
EDAT- 2006/04/04 09:00
MHDA- 2006/06/20 09:00
CRDT- 2006/04/04 09:00
PHST- 2006/01/13 00:00 [received]
PHST- 2006/03/01 00:00 [revised]
PHST- 2006/03/09 00:00 [accepted]
PHST- 2006/04/04 09:00 [pubmed]
PHST- 2006/06/20 09:00 [medline]
PHST- 2006/04/04 09:00 [entrez]
AID - S1570-0232(06)00237-6 [pii]
AID - 10.1016/j.jchromb.2006.03.020 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2006 May 1;835(1-2):90-9. doi: 
      10.1016/j.jchromb.2006.03.020. Epub 2006 Mar 31.