PMID- 16580493
OWN - NLM
STAT- MEDLINE
DCOM- 20060501
LR  - 20181201
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 64
IP  - 5
DP  - 2006 Apr 1
TI  - Hypofractionated high-dose irradiation for the treatment of malignant 
      astrocytomas using simultaneous integrated boost technique by IMRT.
PG  - 1317-24
AB  - PURPOSE: We evaluated the clinical significance of hypofractionated high-dose 
      irradiation using simultaneous integrated boost technique with 
      intensity-modulated radiation therapy (IMRT) for the treatment of malignant 
      astrocytomas (MAs). METHODS AND MATERIALS: Twenty-five patients with MAs were 
      treated by IMRT. Three layered planning target volumes (PTVs) were contoured. 
      PTV-1 was the area of enhanced lesion with 5-mm margin; PTV-2 was the area with 
      15-mm margin surrounding the PTV-1; PTV-3 was the area of perifocal edema. 
      Irradiation was performed in 8 fractions, and only the dose for PTV-1 was 
      escalated from 48 Gy to 68 Gy while maintaining the dose for PTV-2 (40 Gy) and 
      PTV-3 (32 Gy). The clinical outcome of IMRT was compared with 60 MA patients 
      treated by conventional external beam irradiation (EBI). RESULTS: The 
      progression-free survival of patients in the IMRT group was significantly longer 
      than that in the EBI group (p < 0.0001). No distant failure was observed in both 
      groups. In the IMRT group, dissemination was the most frequent cause of death 
      (70%). The overall survival of patients in the IMRT group was better than that in 
      the EBI group (p = 0.043). CONCLUSIONS: Our regimen of IMRT contributed to the 
      control of both the regional and infiltrating tumors, resulting in better 
      survival of patients.
FAU - Iuchi, Toshihiko
AU  - Iuchi T
AD  - Division of Neurological Surgery, Chiba Cancer Center, Chiba, Japan.
FAU - Hatano, Kazuo
AU  - Hatano K
FAU - Narita, Yuichiro
AU  - Narita Y
FAU - Kodama, Takashi
AU  - Kodama T
FAU - Yamaki, Tomohiro
AU  - Yamaki T
FAU - Osato, Katsunobu
AU  - Osato K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Astrocytoma/cerebrospinal fluid/pathology/*radiotherapy/surgery
MH  - Brain Neoplasms/cerebrospinal fluid/pathology/*radiotherapy/surgery
MH  - Dose Fractionation, Radiation
MH  - Female
MH  - Follow-Up Studies
MH  - Glioblastoma/cerebrospinal fluid/pathology/*radiotherapy/surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Radiotherapy, Intensity-Modulated/adverse effects/*methods
MH  - Survival Analysis
EDAT- 2006/04/04 09:00
MHDA- 2006/05/02 09:00
CRDT- 2006/04/04 09:00
PHST- 2005/01/28 00:00 [received]
PHST- 2005/11/18 00:00 [revised]
PHST- 2005/12/18 00:00 [accepted]
PHST- 2006/04/04 09:00 [pubmed]
PHST- 2006/05/02 09:00 [medline]
PHST- 2006/04/04 09:00 [entrez]
AID - S0360-3016(05)02992-5 [pii]
AID - 10.1016/j.ijrobp.2005.12.005 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2006 Apr 1;64(5):1317-24. doi: 
      10.1016/j.ijrobp.2005.12.005.