PMID- 16581172
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20220318
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 30
IP  - 5
DP  - 2006 Jul
TI  - Brain-derived neurotrophic factor gene (BDNF) variants and schizophrenia: an 
      association study.
PG  - 924-33
AB  - Polymorphisms in the brain-derived neurotrophic factor (BDNF) gene have been 
      suggested to be associated with schizophrenia. In a replication attempt, Swedish 
      patients with schizophrenia (n=187) and control subjects (n=275) were assessed 
      for four BDNF gene polymorphisms. There were no significantly different allele, 
      genotype or haplotype frequencies between cases or controls. Neither were there 
      any differences when schizophrenic patients were sub-divided with regard to a 
      number of different clinical variables, although a small group of psychotic 
      patients with prominent affective features displayed higher frequencies of the 
      less common alleles of the Val66Met and 11757 G/C polymorphisms compared to 
      controls. The present Swedish results do not verify previous associations between 
      putative functional BDNF gene polymorphisms and schizophrenia. However, when 
      combined with previous studies meta-analyses indicated that the BDNF 270 T-allele 
      and the Val66Met homozygous state were associated with the disorder. Thus, the 
      BDNF gene may confer susceptibility to schizophrenia. Additional studies are 
      warranted to shed further light on this possibility.
FAU - Jonsson, Erik G
AU  - Jonsson EG
AD  - Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and 
      Hospital, R5:00, SE-171 76 Stockholm, Sweden. erik.jonsson@ki.se
FAU - Edman-Ahlbom, Bodil
AU  - Edman-Ahlbom B
FAU - Sillen, Anna
AU  - Sillen A
FAU - Gunnar, Agneta
AU  - Gunnar A
FAU - Kulle, Bettina
AU  - Kulle B
FAU - Frigessi, Arnoldo
AU  - Frigessi A
FAU - Vares, Maria
AU  - Vares M
FAU - Ekholm, Birgit
AU  - Ekholm B
FAU - Wode-Helgodt, Birgitta
AU  - Wode-Helgodt B
FAU - Schumacher, Johannes
AU  - Schumacher J
FAU - Cichon, Sven
AU  - Cichon S
FAU - Agartz, Ingrid
AU  - Agartz I
FAU - Sedvall, Goran C
AU  - Sedvall GC
FAU - Hall, Hakan
AU  - Hall H
FAU - Terenius, Lars
AU  - Terenius L
LA  - eng
GR  - 44814/PHS HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060403
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Amino Acid Substitution
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Variation
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Middle Aged
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Schizophrenia/*epidemiology/*genetics
MH  - Sweden/epidemiology
EDAT- 2006/04/04 09:00
MHDA- 2006/08/19 09:00
CRDT- 2006/04/04 09:00
PHST- 2006/04/04 09:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2006/04/04 09:00 [entrez]
AID - S0278-5846(06)00069-8 [pii]
AID - 10.1016/j.pnpbp.2006.02.008 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jul;30(5):924-33. doi: 
      10.1016/j.pnpbp.2006.02.008. Epub 2006 Apr 3.